4-Hydroxy-4-phenylpiperidine
4-Hydroxy-4-phenylpiperidine (CAS 40807-61-2, C11H15NO) is a versatile piperidine derivative with a molecular weight of 177.24 g/mol. Primarily used as a key building block in complex organic synthesis, it serves as a reactant in the development of various pharmacologically active compounds. Its structure makes it valuable for creating novel molecules with potential applications in medicinal chemistry.
- IUPAC
- 4-Phenyl-4-piperidinol
- Synonyms
- 4-Phenyl-4-piperidinol
Synthesis of hNav1.7 Inhibitors
4-Hydroxy-4-phenylpiperidine is utilised as a reactant in the synthesis of diaminotriazine hNav1.7 inhibitors, which are investigated for their potential therapeutic applications.
Development of Selective Ligands
This compound serves as a precursor in the preparation of selective and ligands, contributing to research in neurochemistry and pharmacology.
Glycogen Synthase Kinase-3β Inhibitors
It functions as a reactant in the synthetic pathways leading to glycogen synthase kinase-3β inhibitors, compounds studied for various cellular processes.
Inducers of Cell Autophagy
4-Hydroxy-4-phenylpiperidine is employed in the synthesis of diphenylbutylpiperidines, which are explored as agents that induce cell autophagy.
Antiobesity and Antidiabetic Agents
The compound is a reactant in the development of malonyl-CoA decarboxylase inhibitors, investigated for their potential antiobesity and antidiabetic activities.
Dopamine Receptor Antagonists
It is used in the synthesis of selective dopamine D2 receptor antagonists, which are of interest in neurological research.
| Molecular weight | 177.24 |
|---|---|
| Empirical formula | C11H15NO |
| Assay | 99% |
| Application | Reactant for synthesis of:• Diaminotriazine hNav1.7 inhibitors1• Selective &;−ligands2• Glycogen synthase kinase-3β−inhibitors3• Diphenylbutylpiperidines as cell autophagy inducers4• Malonyl-coA decarboxylase inhibitors with antiobesity and antidiabetic activities5• Selective dopamine D2 receptor antagonists6 |
| Melting point | 157-161 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxy-4-phenylpiperidine used for?
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4-Hydroxy-4-phenylpiperidine is primarily used as a building block and reactant in organic synthesis, particularly for the development of various pharmacologically active compounds such as hNav1.7 inhibitors, selective ligands, and dopamine receptor antagonists.
What is the CAS number and molecular formula for 4-Hydroxy-4-phenylpiperidine?
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The CAS number for 4-Hydroxy-4-phenylpiperidine is 40807-61-2, and its molecular formula is C11H15NO.
What grade and purity does Tech Serve Solutions supply for 4-Hydroxy-4-phenylpiperidine?
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Tech Serve Solutions supplies 4-Hydroxy-4-phenylpiperidine with an assay of 99%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Hydroxy-4-phenylpiperidine be handled safely?
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4-Hydroxy-4-phenylpiperidine is classified as a warning substance. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid dust formation.
How is 4-Hydroxy-4-phenylpiperidine packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports fine chemicals globally. Specific packaging details are available upon request to ensure safe transit and compliance with international shipping regulations.
How can I request a sample or quote for 4-Hydroxy-4-phenylpiperidine?
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To request a sample or a quote for 4-Hydroxy-4-phenylpiperidine, please use the contact form on our website or reach out to our sales team directly. Please specify the quantity required and your shipping destination.
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