(4-Ethoxybenzyl)triphenylphosphonium bromide
(4-Ethoxybenzyl)triphenylphosphonium bromide (CAS: 82105-88-2) is a phosphonium salt with the molecular formula C2H5OC6H4CH2P(C6H5)3Br and a molecular weight of 477.37 g/mol. This compound is primarily utilised as a reagent in organic synthesis. Its key application lies in facilitating carbon-carbon bond formation through Wittig reactions, enabling the synthesis of various organic molecules, including pharmaceutical intermediates.
Wittig Reaction Reagent
Used as a reactant in Wittig reactions for the preparation of styrylquinolones, a class of compounds with potential biological activity. This reaction is crucial for forming carbon-carbon double bonds.
Synthesis of Indolone Derivatives
Applied in the synthesis of indolone-N-oxides, which have demonstrated activity as antiplasmodial and anticancer agents. The phosphonium salt enables the construction of the required molecular framework.
Pharmaceutical Intermediate Synthesis
Serves as a key reagent in the assembly of the pyrimidinone core of Raltegravir potassium, an HIV integrase inhibitor. The Wittig reaction is employed to build this critical structural element.
| Molecular weight | 477.37 |
|---|---|
| Linear formula | C2H5OC6H4CH2P(C6H5)3Br |
| Assay | 99% |
| Application | Reactant for:• Preparation of styrylquinolones by Wittig reaction1• Preparation of indolone-N-oxides as antiplasmodial and anticancer agents2• Assembly of pyrimidinone core of HIV integrase inhibitor raltegravir potassium, via Wittig reaction3 |
| Melting point | 214-215 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (4-Ethoxybenzyl)triphenylphosphonium bromide used for?
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(4-Ethoxybenzyl)triphenylphosphonium bromide is used as a reagent in organic synthesis, particularly in Wittig reactions for the preparation of styrylquinolones, indolone-N-oxides, and intermediates for pharmaceuticals like Raltegravir potassium.
What are the CAS number and formula for (4-Ethoxybenzyl)triphenylphosphonium bromide?
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The CAS number is 82105-88-2 and the linear formula is C2H5OC6H4CH2P(C6H5)3Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (4-Ethoxybenzyl)triphenylphosphonium bromide with an assay of 99%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
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This compound is a Warning substance and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (4-Ethoxybenzyl)triphenylphosphonium bromide, catering to international markets.
How can I request a sample or quote?
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To request a sample or a quotation for (4-Ethoxybenzyl)triphenylphosphonium bromide, please contact our sales department through the website or via direct inquiry, specifying your requirements.
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