(4-Chlorobenzyl)triphenylphosphonium chloride
(4-Chlorobenzyl)triphenylphosphonium chloride (CAS: 1530-39-8, Formula: ClC6H4CH2P(C6H5)3Cl, MW: 423.31) is a phosphonium salt widely employed as a synthetic reagent. It is particularly valuable in C-C bond formation and olefination reactions, most notably the Wittig reaction. This compound serves as a key intermediate in the synthesis of various complex organic molecules, including biologically active compounds and functional materials, making it a staple in chemical synthesis laboratories.
- IUPAC
- [(4-Chlorophenyl)methyl]triphenylphosphonium chloride
Synthesis of β-Amyloid Plaque Ligands
This phosphonium salt acts as a reactant in the preparation of molecules designed to interact with β-amyloid plaques, which are implicated in neurodegenerative diseases.
Preparation of Aspartate Analog Inhibitors
It is utilised in the synthesis of selective norbornane-type aspartate analog inhibitors targeting glutamate transporter 1, relevant for neurological research.
Insecticidal Pyrethroid Synthesis
The compound serves as a building block for the creation of pyrethroids, a class of insecticides known for their efficacy.
Antifungal Compound Development
It is employed in the synthesis of chlorinated aromatic avenaciolide analogs, which have demonstrated antifungal properties.
Wittig-Boden Reactions
Used in Wittig-Boden reactions to synthesise arylethenylbenzofuroxan derivatives, contributing to the development of novel organic structures.
Synthesis of Styrylchromones
Serves as a reagent in Wittig reactions for the preparation of styrylchromones, a class of compounds with diverse applications.
| Molecular weight | 423.31 |
|---|---|
| Linear formula | ClC6H4CH2P(C6H5)3Cl |
| Assay | 98% |
| Application | Reactant for the synthesis of: • β-amyloid plaque ligands1• Selective norbornane-type aspartate analog inhibitors of glutamate transporter 12• Pyrethroids with insecticidal activity3• Chlorinated aromatic avenaciolide analogs with antifungal activity4• Arylethenylbenzofuroxan derivatives via Wittig-Boden reactions5• Substituted benzofuroxans for inhibition of Trypanosoma cruzi growth6• Styrylchromones via Wittig reactions7 |
| Melting point | >300 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (4-Chlorobenzyl)triphenylphosphonium chloride used for?
+
(4-Chlorobenzyl)triphenylphosphonium chloride is primarily used as a synthetic reagent in organic chemistry for C-C bond formation and olefination reactions, particularly the Wittig reaction, enabling the synthesis of complex molecules like pyrethroids, inhibitors, and various aromatic compounds.
What is the CAS number and molecular formula?
+
The CAS number for (4-Chlorobenzyl)triphenylphosphonium chloride is 1530-39-8, and its molecular formula is ClC6H4CH2P(C6H5)3Cl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (4-Chlorobenzyl)triphenylphosphonium chloride with an assay of 98%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling precautions for this compound?
+
This compound is a Warning substance and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Ensure good ventilation and avoid inhalation of dust.
How is (4-Chlorobenzyl)triphenylphosphonium chloride packed and shipped?
+
Products are carefully packed according to international shipping regulations. Specific packaging details and export capabilities can be confirmed upon inquiry.
How can I request a quote or sample?
+
To request a quote or a sample of (4-Chlorobenzyl)triphenylphosphonium chloride, please contact our sales team through the website or via email, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis