4-Chloro-L-phenylalanine
4-Chloro-L-phenylalanine (CAS: 14173-39-8), with the molecular formula ClC6H4CH2CH(NH2)CO2H and a molecular weight of 199.63 g/mol, is an unnatural amino acid derivative. It functions as a selective inhibitor of Tryptophan Hydroxylase (TPH), an enzyme crucial for serotonin biosynthesis. This compound is primarily used in biochemical research for studying neurotransmitter metabolism and neurological pathways.
- IUPAC
- L-PCPA
Biochemical Research Tool
Utilised as a selective inhibitor of Tryptophan Hydroxylase (TPH) in biochemical and pharmacological research. It aids in the study of serotonin production pathways and the function of this critical neurotransmitter.
Neuroscience Research
Applied in neuroscience to investigate the roles of serotonin in brain function, mood regulation, and various neurological disorders. Its inhibitory action helps elucidate the consequences of reduced serotonin synthesis.
Enzyme Inhibition Studies
Serves as a valuable tool for in vitro and in vivo studies focusing on enzyme kinetics and mechanisms, specifically targeting TPH enzymes in different species.
Chemical Biology Probe
Employed as a probe in chemical biology to explore cellular signaling pathways affected by altered neurotransmitter levels and to understand the broader implications of metabolic disturbances.
| Molecular weight | 199.63 |
|---|---|
| Linear formula | ClC6H4CH2CH(NH2)CO2H |
| Storage temperature | −20°C |
| Melting point | 263 °C (dec.)(lit.) |
Hazard statements
- H301Toxic if swallowed
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-43 |
| Safety statements (S) | 36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... TPH1(7166), TPH2(121278)mouse ... TPH1(21990), TPH2(216343)rat ... TPH1(24848), TPH2(317675) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-L-phenylalanine used for?
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4-Chloro-L-phenylalanine (CAS: 14173-39-8) is used in biochemical research as a selective inhibitor of Tryptophan Hydroxylase (TPH), aiding in the study of serotonin biosynthesis and its role in neuroscience and neurotransmitter metabolism.
What is the CAS number and chemical formula for 4-Chloro-L-phenylalanine?
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The CAS number for 4-Chloro-L-phenylalanine is 14173-39-8, and its chemical formula is ClC6H4CH2CH(NH2)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-L-phenylalanine for research purposes. The specific grade and purity are detailed in the product's specifications. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated.
How should 4-Chloro-L-phenylalanine be handled safely?
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Due to its toxic nature (H301, H317), handling 4-Chloro-L-phenylalanine requires strict precautions. Use appropriate personal protective equipment including eyeshields, faceshields, gloves, and a P2 respirator. Work should be conducted in a well-ventilated area or fume hood. Refer to the safety data sheet for full handling instructions.
How is 4-Chloro-L-phenylalanine packed, shipped, and exported?
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4-Chloro-L-phenylalanine is packed according to international shipping regulations for hazardous materials (UN 2811 6.1 / PGIII). TSS can facilitate global export to approved destinations.
How can I request a sample or quote for 4-Chloro-L-phenylalanine?
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To request a sample or a quotation for 4-Chloro-L-phenylalanine, please contact our sales team through the website or by phone, providing your required quantity and shipping details.
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