4-Chloro-5,8-difluoroquinoline
4-Chloro-5,8-difluoroquinoline (CAS: 874781-04-1) is a fluorinated heterocyclic compound with the molecular formula C9H4ClF2N and a molecular weight of 199.58 g/mol. This quinoline derivative serves as a valuable building block in organic synthesis, particularly for the development of novel chemical entities. Its unique structure, featuring both chlorine and fluorine substituents on the quinoline core, makes it a useful intermediate in the preparation of complex molecules for research and development purposes.
- Synonyms
- C9H4ClF2N

Organic Synthesis Intermediate
This compound is employed as a key intermediate in multi-step organic syntheses. Its reactive sites allow for further functionalization, enabling the construction of more complex molecular architectures.
Pharmaceutical Research
As a fluorinated heterocyclic building block, it is utilised in the discovery and development of new pharmaceutical agents. The quinoline scaffold is prevalent in many biologically active compounds.
Agrochemical Development
The structural features of 4-Chloro-5,8-difluoroquinoline may lend themselves to the synthesis of novel agrochemicals, contributing to the development of new crop protection agents.
Material Science Exploration
Its unique electronic and structural properties can be explored for applications in material science, including the synthesis of functional materials and organic electronics.
| Molecular weight | 199.58 |
|---|---|
| Empirical formula | C9H4ClF2N |


Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-5,8-difluoroquinoline used for?
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4-Chloro-5,8-difluoroquinoline is primarily used as a building block in organic synthesis for the development of novel chemical entities, particularly in pharmaceutical and agrochemical research.
What is the CAS number and formula for 4-Chloro-5,8-difluoroquinoline?
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The CAS number is 874781-04-1 and the molecular formula is C9H4ClF2N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-5,8-difluoroquinoline typically as a research or technical grade chemical. The exact assay and purity are available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated.
How should 4-Chloro-5,8-difluoroquinoline be handled safely?
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4-Chloro-5,8-difluoroquinoline is classified as Danger. It is harmful if swallowed (H302) and causes serious eye damage (H318). Handle with appropriate personal protective equipment, including eye protection (P280, P305+P351+P338). Consult the Safety Data Sheet for detailed handling and emergency procedures.
Is this product suitable for export?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 4-Chloro-5,8-difluoroquinoline, to meet the needs of researchers and industries worldwide.
How can I request a quote or sample?
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To request a quote or a sample of 4-Chloro-5,8-difluoroquinoline, please contact our sales team through the website or by calling our main office. Please specify the quantity and intended use.
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