4′-Chloro-2,2,2-trifluoroacetophenone
4′-Chloro-2,2,2-trifluoroacetophenone (CAS 321-37-9) is a fluorinated ketone and an organic building block with the linear formula ClC₆H₄COCF₃ and a molecular weight of 208.56 g/mol. It serves as a valuable intermediate in chemical synthesis, particularly within the realms of pharmaceutical research and the development of novel organic compounds. Its reactive trifluoromethyl ketone moiety makes it a versatile reagent for introducing the trifluoroacetyl group into various molecular structures.
- IUPAC
- 4-Chloro-α,α,α-trifluoroacetophenone
- Synonyms
- 321-37-9ClC6H4COCF34-Chloro-α,α,α-trifluoroacetophenone
Pharmaceutical Intermediate
Utilised in the synthesis of complex pharmaceutical agents and drug candidates. Its structure allows for the incorporation of a trifluoromethyl group, which can enhance drug properties like metabolic stability and lipophilicity.
Organic Synthesis Reagent
A key building block for creating specialised organic molecules. The presence of both a chlorine atom and a trifluoroacetyl group offers multiple reaction sites for further chemical transformations.
Research and Development
Employed in academic and industrial research laboratories for the exploration of new chemical entities and reaction pathways. It is valuable for creating diverse chemical libraries.
| Molecular weight | 208.56 |
|---|---|
| Linear formula | ClC6H4COCF3 |
| Assay | 99% |
| Boiling point | 180-183 °C(lit.) |
| Density | 1.398 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.489(lit.) |
| Melting point | 24-26 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 78 °C / 172.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4′-Chloro-2,2,2-trifluoroacetophenone used for?
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4′-Chloro-2,2,2-trifluoroacetophenone is primarily used as a building block and intermediate in organic synthesis, particularly in the development of pharmaceuticals and other complex organic molecules. It is also utilised in research and development for exploring new chemical entities.
What is the CAS number and formula for 4′-Chloro-2,2,2-trifluoroacetophenone?
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The CAS number is 321-37-9 and the linear formula is ClC₆H₄COCF₃.
What grade and purity does Tech Serve Solutions supply for 4′-Chloro-2,2,2-trifluoroacetophenone?
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Tech Serve Solutions supplies 4′-Chloro-2,2,2-trifluoroacetophenone with a minimum assay of 99%. This product is intended for research and technical applications. Tech Serve Solutions does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4′-Chloro-2,2,2-trifluoroacetophenone be handled safely?
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Handling requires appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. It is classified as a Warning with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Ensure good ventilation and avoid breathing dust.
Is 4′-Chloro-2,2,2-trifluoroacetophenone packed, shipped, or exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions, a specialist global supplier and exporter, routinely handles the packing, shipping, and export of chemicals like 4′-Chloro-2,2,2-trifluoroacetophenone to customers worldwide.
How can I request a sample or quote for 4′-Chloro-2,2,2-trifluoroacetophenone?
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To request a sample or a quote for 4′-Chloro-2,2,2-trifluoroacetophenone, please contact our sales team through the website or by phone, providing your requirements and contact details.
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