4-Bromoquinoline
4-Bromoquinoline (CAS 3964-04-3; C9H6BrN; molecular weight 208.05) is a halogenated quinoline building block bearing a reactive carbon-bromine bond at the 4-position of the bicyclic heteroaromatic ring. It is a low-melting solid (29-34 degC) supplied at 95% assay for research and chemical synthesis. The 4-bromo handle makes it a versatile intermediate for transition-metal-catalysed cross-coupling and nucleophilic substitution in pharmaceutical, agrochemical and materials discovery programmes. Tech Serve Solutions supplies and exports 4-Bromoquinoline worldwide.
- Synonyms
- 4-Bromoquinoline4-Bromochinolinquinoline, 4-bromo-4-bromoquinolinCAS 3964-04-3
Heterocyclic building block
Serves as a C8-C10 quinoline scaffold for constructing more elaborate heteroaromatic compounds. The 4-position bromide provides a defined, regioselective site for further functionalisation.
Transition-metal cross-coupling
The activated aryl bromide participates in palladium- and nickel-catalysed couplings such as Suzuki-Miyaura, Stille, Negishi and Sonogashira reactions to form new carbon-carbon bonds at the 4-position.
Carbon-nitrogen bond formation
Undergoes Buchwald-Hartwig amination and nucleophilic aromatic substitution to install amines and other nucleophiles, giving access to 4-substituted quinoline derivatives.
Pharmaceutical and agrochemical discovery
The quinoline nucleus is a recurring motif in medicinal and crop-protection chemistry, and 4-Bromoquinoline is used as a starting material in early-stage discovery and route-scouting work.
Materials and ligand synthesis
Functionalised quinolines derived from this intermediate are explored in coordination chemistry, luminescent materials and functional organic compounds.
| Molecular weight | 208.05 |
|---|---|
| Empirical formula | C9H6BrN |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Melting point | 29-34 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromoquinoline used for?
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4-Bromoquinoline is used primarily as a heterocyclic building block in organic synthesis. Its reactive carbon-bromine bond at the 4-position makes it a substrate for transition-metal-catalysed cross-coupling (Suzuki, Stille, Sonogashira) and nucleophilic substitution, supporting pharmaceutical, agrochemical and materials research.
What is the CAS number and molecular formula of 4-Bromoquinoline?
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4-Bromoquinoline has the CAS number 3964-04-3 and the molecular formula C9H6BrN, with a molecular weight of 208.05 g/mol. Its MDL number is MFCD07644514.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromoquinoline at a typical assay of 95%, suitable for chemical synthesis and research use. A certificate of analysis accompanies each batch. We do not represent it as a pharmacopoeial (USP/BP/EP) grade unless specifically agreed.
What are the safety and handling requirements for 4-Bromoquinoline?
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4-Bromoquinoline is classified under GHS with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask in a well-ventilated area, avoiding dust formation. Always consult the Safety Data Sheet before use.
How should 4-Bromoquinoline be stored?
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Store 4-Bromoquinoline refrigerated at 2-8 degC in a tightly closed container, protected from moisture. It is a low-melting solid (melting point 29-34 degC), so cool storage helps maintain it in a solid, easily handled form. Refer to the SDS for full storage guidance.
How is 4-Bromoquinoline packed, shipped and exported?
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4-Bromoquinoline is packed in sealed, labelled containers sized to the order, from gram quantities to bulk, with cold-chain or insulated handling where required. Tech Serve Solutions exports worldwide with full documentation, including the SDS and certificate of analysis, in line with applicable transport regulations.
How do I request a sample or quote for 4-Bromoquinoline?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for qualification, subject to regulatory and shipping requirements.
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