4-Bromomethyl-6,7-dimethoxycoumarin
4-Bromomethyl-6,7-dimethoxycoumarin (CAS 88404-25-5) is a halogenated heterocyclic compound with a molecular weight of 299.12 g/mol. This chemical serves as a valuable fluorescent labeling reagent, particularly for the reversed-phase HPLC separation and detection of carboxylic acids. Its utility extends to various derivatization applications in analytical chemistry, contributing to precise quantitative analysis in diverse matrices.
- Synonyms
- C12H11BrO44-(Bromomethyl)-6,7-dimethoxy-2H-chromen-2-one
Fluorescent Labeling Reagent
4-Bromomethyl-6,7-dimethoxycoumarin is employed as a fluorescent derivatization reagent for the sensitive detection and separation of carboxylic acids using reversed-phase High-Performance Liquid Chromatography (HPLC).
Quantitation of Bile Acids
It is utilised for the quantitative determination of clofibric, bezafibric, and fenofibric acids in liver samples through liquid chromatography methods.
Glutathione Determination
This reagent can be used in the determination of tripeptide glutathione concentrations via matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).
Chromatographic Detection of Carboxylic Acids
Its fluorescent properties enable its use in chromatographic detection methods for a range of carboxylic acids.
| Molecular weight | 299.12 |
|---|---|
| Empirical formula | C12H11BrO4 |
| Assay | 96% |
| Application | 4-Bromomethyl-6,7-dimethoxycoumarin was used as fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids.1,2 It was also used as derivatization reagent:• for quantitation of clofibric, bezafibric and fenofibric acids in liver by liquid chromatography3• in determination of the concentration of tripeptide glutathione by matrix-assisted laser desorption ionization time-of-flight mass spectrometry4• for determination of carboxylic acids in chromatographic detection5 |
| Melting point | 212-216 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 322; λem 395 (Reaction product with acetic acid)λex 354 nm; λem 435 nm in methanol |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromomethyl-6,7-dimethoxycoumarin used for?
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4-Bromomethyl-6,7-dimethoxycoumarin is primarily used as a fluorescent labeling reagent for the HPLC separation and detection of carboxylic acids, and as a derivatization reagent for quantitative analysis in various matrices.
What are the CAS number and formula for 4-Bromomethyl-6,7-dimethoxycoumarin?
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The CAS number is 88404-25-5 and the empirical formula is C12H11BrO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromomethyl-6,7-dimethoxycoumarin with an assay of 96%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
What are the safety and handling precautions for this compound?
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This compound is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. It is recommended to wear a dust mask (type N95), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of contact, rinse cautiously with water. Refer to the Safety Data Sheet for comprehensive handling information.
How is 4-Bromomethyl-6,7-dimethoxycoumarin packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions exports fine chemicals worldwide, adhering to all relevant shipping and customs regulations for safe and compliant international delivery.
How can I request a sample or quote for 4-Bromomethyl-6,7-dimethoxycoumarin?
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To request a sample or a quotation, please contact our sales department through the provided channels on the Tech Serve Solutions website.
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