4-Bromo-α-methylbenzyl alcohol
4-Bromo-α-methylbenzyl alcohol (CAS 5391-88-8), with the molecular formula BrC6H4CH(CH3)OH and a molecular weight of 201.06 g/mol, is a valuable organic building block. This compound serves as a precursor in various chemical syntheses. Its structure, featuring a brominated phenyl ring and a secondary alcohol group, makes it suitable for reactions like etherification and oxidation, leading to more complex molecular architectures for research and development purposes.
Synthesis of Diazirine Derivatives
4-Bromo-α-methylbenzyl alcohol has been utilised in the preparation of specialised organic compounds, such as 3-(4-(1-(tert-butyl)dimethylsilyloxy)ethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine. This highlights its role in creating complex heterocyclic structures for advanced chemical research.
Preparation of Silyl Ethers
The alcohol moiety of 4-Bromo-α-methylbenzyl alcohol can be protected or functionalised. It has been used in syntheses leading to protected intermediates, like (1-(4-bromophenyl)ethoxy)(tert-butyl)dimethylsilane, demonstrating its utility in multi-step synthetic strategies.
Organic Synthesis Intermediate
As a functionalised aromatic alcohol, this compound is a useful intermediate in organic synthesis. It allows for the introduction of a bromophenyl and a chiral secondary alcohol group into target molecules, facilitating the construction of diverse chemical entities.
| Molecular weight | 201.06 |
|---|---|
| Linear formula | BrC6H4CH(CH3)OH |
| Assay | 97% |
| Boiling point | 119-121 °C/7 mmHg(lit.) |
| Density | 1.46 g/mL at 25 °C(lit.) |
| Application | 4-Bromo-α-methylbenzyl alcohol was used in the synthesis of 3-(4-(1-(tert-butyl)dimethylsilyloxy)ethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine and (1-(4-bromophenyl)ethoxy)(tert-butyl)dimethylsilane1. |
| Melting point | 36-38 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 63 °C / 145.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-α-methylbenzyl alcohol primarily used for?
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4-Bromo-α-methylbenzyl alcohol is used as an intermediate in organic synthesis for creating more complex molecules, including specialised diazirine and silyl ether derivatives.
What is the CAS number and chemical formula for 4-Bromo-α-methylbenzyl alcohol?
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The CAS number is 5391-88-8 and the chemical formula is BrC6H4CH(CH3)OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-α-methylbenzyl alcohol with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Bromo-α-methylbenzyl alcohol be handled?
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This compound is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation. Wear a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash thoroughly after handling. Avoid release to the environment.
Is 4-Bromo-α-methylbenzyl alcohol a controlled substance?
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Based on the provided data, 4-Bromo-α-methylbenzyl alcohol is not listed as a controlled substance.
How is 4-Bromo-α-methylbenzyl alcohol typically packed and exported?
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Tech Serve Solutions securely packs and exports chemicals adhering to international shipping regulations to ensure safe transit worldwide.
How can I request a sample or quote for 4-Bromo-α-methylbenzyl alcohol?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone, providing the product name and CAS number (5391-88-8).
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