4-Bromo-1-naphthaleneboronic acid
4-Bromo-1-naphthaleneboronic acid (CAS: 145965-14-6), with the molecular formula C10H8BBrO2 and a molecular weight of 250.88, is a specialised aryl boronic acid. It serves as a key reactant in various organic synthesis pathways. Its utility is highlighted in Suzuki couplings for preparing substituted enones, in copper-catalyzed oxidative cross-coupling reactions, and in the microwave-assisted synthesis of ethynylarylboronates, making it a valuable intermediate for complex molecule construction.
- IUPAC
- (4-Bromonaphthalen-1-yl)boronic acid,1-Bromonaphthalene-4-boronic acid
- Synonyms
- (4-Bromonaphthalen-1-yl)boronic acid1-Bromonaphthalene-4-boronic acid
Suzuki Coupling Reagent
This compound acts as a reactant in Suzuki coupling reactions, facilitating the preparation of 3,5-substituted enones. This transformation is crucial for building complex organic structures.
Copper-Catalyzed Oxidative Cross-Coupling
It participates in copper-catalyzed oxidative cross-coupling reactions. This application allows for the formation of new carbon-carbon bonds under specific catalytic conditions.
Microwave-Assisted Synthesis
The boronic acid is employed in microwave-assisted synthesis for the preparation of ethynylarylboronates. This method offers efficient and accelerated synthetic routes.
| Molecular weight | 250.88 |
|---|---|
| Empirical formula | C10H8BBrO2 |
| Application | Reactant for:• Preparation of 3,5-substituted enones via Suzuki coupling1• Copper catalyzed oxidative cross-coupling2• Microwave-assisted synthesis of ethynylarylboronates3 |
| Melting point | 230-260 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-1-naphthaleneboronic acid used for?
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4-Bromo-1-naphthaleneboronic acid is used as a reactant in organic synthesis, notably for Suzuki coupling, copper-catalyzed oxidative cross-coupling, and microwave-assisted synthesis of ethynylarylboronates.
What is the CAS number and formula for 4-Bromo-1-naphthaleneboronic acid?
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The CAS number is 145965-14-6, and the empirical formula is C10H8BBrO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The exact grade and purity are available on the product's Certificate of Analysis. It is not supplied as USP, BP, or EP grade.
How should 4-Bromo-1-naphthaleneboronic acid be handled?
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This compound is a Warning substance, classified with H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Handle with a dust mask (N95 type), eyeshields, and gloves in a well-ventilated area.
Is 4-Bromo-1-naphthaleneboronic acid a controlled substance?
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No, the provided data does not indicate that 4-Bromo-1-naphthaleneboronic acid is a controlled substance.
How is 4-Bromo-1-naphthaleneboronic acid packed and shipped?
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Tech Serve Solutions packs and ships fine chemicals, pharmaceutical intermediates, and laboratory reagents globally. Specific packing details for export are available upon request.
How can I request a quote or sample?
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To request a quote or sample of 4-Bromo-1-naphthaleneboronic acid, please contact the Tech Serve Solutions sales team through our website or designated contact channels.
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