4-Amino-1-benzylpiperidine
4-Amino-1-benzylpiperidine (CAS: 50541-93-0) is a chemical compound with the formula C12H18N2 and a molecular weight of 190.28 g/mol. This piperidine derivative serves as a valuable building block in organic synthesis. Its applications primarily lie in the preparation of more complex molecules, including pharmaceutical intermediates and bioactive compounds, leveraging its reactive amino group and piperidine ring structure.
- IUPAC
- 1-(Phenylmethyl)-4-piperidinamine
Preparation of Pharmaceutical Intermediates
4-Amino-1-benzylpiperidine is utilized in synthesising key intermediates for active pharmaceutical ingredients. For instance, it is a precursor in the preparation of butyl 4-amino-1-piperidineacetate, which is essential for the synthesis of related acetamide derivatives.
Synthesis of Heterocyclic Compounds
This compound acts as a building block for constructing complex heterocyclic structures. It has been employed in the synthesis of 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one.
Development of Glycyrrhetinic Acid Derivatives
4-Amino-1-benzylpiperidine finds application in the modification and synthesis of glycyrrhetinic acid derivatives. This highlights its role in medicinal chemistry research for developing novel therapeutic agents.
| Molecular weight | 190.28 |
|---|---|
| Empirical formula | C12H18N2 |
| Assay | 98% |
| Density | 0.933 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.543(lit.) |
| Application | 4-Amino-1-benzylpiperidine was used in the preparation of:• butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate1• 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-one2• glycyrrhetinic acid derivatives3 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Grin2a(24409) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Amino-1-benzylpiperidine used for?
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4-Amino-1-benzylpiperidine is primarily used as a building block in organic synthesis, particularly for preparing pharmaceutical intermediates and complex heterocyclic compounds like certain glycyrrhetinic acid derivatives and thiadiazolidin-3-ones.
What are the CAS number and formula for 4-Amino-1-benzylpiperidine?
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The CAS number for 4-Amino-1-benzylpiperidine is 50541-93-0, and its empirical formula is C12H18N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Amino-1-benzylpiperidine with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Amino-1-benzylpiperidine be handled safely?
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4-Amino-1-benzylpiperidine is classified with Warning signal word and hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including eyeshields and gloves, should be worn, and handling should occur in a well-ventilated area. A suitable respirator filter, such as type ABEK, is recommended.
Is 4-Amino-1-benzylpiperidine available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Amino-1-benzylpiperidine, and can accommodate international orders.
How can I request a quote or sample?
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To request a quote or a sample of 4-Amino-1-benzylpiperidine, please contact our sales team through the website or by phone, providing your specific requirements.
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