4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester
4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester (CAS: 79886-55-8; Formula: C18H16N2O6; Molar Mass: 356.33 g/mol) is a heterobifunctional cross-linking reagent. It features a maleimide group that reacts with thiols and an N-hydroxysuccinimide (NHS) ester that reacts with primary amines. This dual functionality allows for the specific conjugation of molecules in chemical biology and protein modification studies.
- IUPAC
- 4-(4-Maleimidophenyl)butyric acid N-succinimidyl ester,4-(4-Maleimidophenyl)butyric acid NHS ester,N-Succinimidyl 4-(4-maleimidophenyl)butyrate,SMPB
- Synonyms
- N-Succinimidyl 4-(4-maleimidophenyl)butyrate4-(4-Maleimidophenyl)butyric acid NHS esterSMPB
Protein Cross-linking
This reagent is used to covalently link proteins through reactions with amine and thiol groups. It is valuable for studying protein structure, interactions, and for immobilizing proteins onto surfaces.
Bioconjugation
The heterobifunctional nature of this compound makes it suitable for creating conjugates between different biomolecules, such as attaching peptides or antibodies to surfaces or other proteins.
Chemical Biology Research
Utilised in chemical biology for targeted modifications of biological molecules, enabling the study of cellular processes and the development of novel biochemical tools.
Surface Functionalisation
Can be employed to modify surfaces with reactive groups, facilitating the subsequent attachment of biomolecules for assays or diagnostic applications.
| Molecular weight | 356.33 |
|---|---|
| Empirical formula | C18H16N2O6 |
| Storage temperature | 2-8°C |
| Application | Heterobifunctional cross-linking reagent. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester used for?
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This compound is a heterobifunctional cross-linking reagent used for applications in protein cross-linking, bioconjugation, chemical biology research, and surface functionalisation. It allows for the specific conjugation of molecules through reactions with amine and thiol groups.
What are the CAS number and formula for this compound?
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The CAS number is 79886-55-8 and the molecular formula is C18H16N2O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research purposes. The specific grade and purity are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should this chemical be handled safely?
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This compound is a Warning substance (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.
Is this chemical a controlled substance?
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The provided data does not indicate that this chemical is a controlled substance.
How is this product packed and shipped?
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This product is typically stored at 2-8°C. Packing and shipping adhere to standard regulations for fine chemicals, ensuring product integrity during transit.
How can I request a sample or quote?
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To request a sample or a quote for 4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester, please contact our sales department through the TSS website or by phone.
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