4,4′,4′′-Trimethoxytrityl chloride
4,4′,4′′-Trimethoxytrityl chloride (CAS 49757-42-8) is a versatile organic compound with the molecular formula (CH3OC6H4)3CCl and a molecular weight of 368.85. It serves as a crucial protecting group reagent in organic synthesis, particularly for nucleosides and nucleotides. Its characteristic trityl structure allows for selective protection and deprotection steps in complex multi-step chemical processes.
- Synonyms
- 49757-42-8, (CH3OC6H4)3CCl
Protecting Group in Nucleotide Synthesis
4,4′,4′′-Trimethoxytrityl chloride is widely employed to protect the 5'-hydroxyl group of nucleosides during oligonucleotide synthesis. This protection is essential for ensuring regioselective reactions in the stepwise assembly of DNA and RNA.
Protecting Group in Nucleoside Chemistry
It is used for the selective protection of primary hydroxyl groups in nucleosides and carbohydrates. The resulting dimethoxytrityl ethers are stable under various reaction conditions but readily cleaved under mild acidic treatment.
Reagent in Organic Synthesis
Beyond nucleotide chemistry, this reagent finds application in the synthesis of complex organic molecules where selective hydroxyl protection is required. Its steric bulk and electronic properties make it a valuable tool for chemists.
| Molecular weight | 368.85 |
|---|---|
| Linear formula | (CH3OC6H4)3CCl |
| Melting point | 146-148 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4,4′,4′′-Trimethoxytrityl chloride used for?
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4,4′,4′′-Trimethoxytrityl chloride is primarily used as a protecting group reagent, especially for the 5'-hydroxyl position of nucleosides and nucleotides in oligonucleotide synthesis. It is also applied in broader organic synthesis for selective protection of hydroxyl groups.
What is the CAS number and formula for 4,4′,4′′-Trimethoxytrityl chloride?
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The CAS number is 49757-42-8 and the linear formula is (CH3OC6H4)3CCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a purity typically greater than 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for 4,4′,4′′-Trimethoxytrityl chloride?
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This compound is classified as an irritant. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.
How is 4,4′,4′′-Trimethoxytrityl chloride packed and shipped?
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4,4′,4′′-Trimethoxytrityl chloride is carefully packed in compliance with international shipping regulations. Tech Serve Solutions exports this chemical globally to meet diverse research and manufacturing needs.
How can I request a quote or sample?
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To request a quote or a sample of 4,4′,4′′-Trimethoxytrityl chloride, please contact our sales team through the website or call us directly. Specify your requirements, and we will respond promptly.
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