4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde
4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde (CAS: 35295-36-4) is a fluorinated aromatic aldehyde with the molecular formula C9H6F4O2 and a molecular weight of 222.14 g/mol. This compound serves as a valuable building block in organic synthesis, particularly for the introduction of the tetrafluoroethoxy-substituted benzaldehyde moiety into more complex molecules. Its utility is found in the development of novel materials and pharmaceutical intermediates.
- Synonyms
- 2-(1,1,2,2-Tetrafluoroethoxy)benzaldehydeCHF2CF2OC6H4COH

Organic Synthesis Intermediate
This aldehyde is employed as a key intermediate in multi-step organic syntheses. Its functional groups allow for diverse chemical transformations, making it useful for constructing complex organic structures.
Fluorinated Building Block
As a source of the tetrafluoroethoxy group, it is integral in the synthesis of fluorinated organic compounds. These compounds often exhibit unique physicochemical properties beneficial in various research and development applications.
Pharmaceutical Research
The compound can be utilised in the synthesis of potential pharmaceutical agents. Fluorine incorporation can modulate drug properties such as metabolic stability and bioavailability.
Materials Science
It may find application in the development of advanced materials where fluorinated substituents can impart desirable characteristics like thermal stability or specific electronic properties.
| Molecular weight | 222.14 |
|---|---|
| Linear formula | CHF2CF2OC6H4COH |
| Assay | 97% |
| Boiling point | 227 °C(lit.) |
| Density | 1.343 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.46(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde used for?
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4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde is primarily used as a building block and intermediate in organic synthesis, particularly for creating fluorinated organic compounds, potentially for pharmaceutical research and materials science applications.
What is the CAS number and molecular formula?
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The CAS number for 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde is 35295-36-4 and its molecular formula is C9H6F4O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 97%. It is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde be handled?
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This compound is a warning irritant. Handle with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling information.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and can arrange for the shipment and export of 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde according to international regulations.
How can I request a sample or quote?
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To request a sample or a quote for 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde, please contact the Tech Serve Solutions sales team through our website or by phone.
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