3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile

CAS 361456-00-0C12H17N3O3SiChemical Synthesis

3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile (CAS 361456-00-0) is a specialized organic compound with the molecular formula C12H17N3O3Si and a molecular weight of 279.37 g/mol. This pyridine derivative serves as a valuable building block in complex chemical synthesis. Its structure incorporates a nitro group, an ether linkage with a silyl protecting group, and a nitrile functional group, making it suitable for diverse synthetic transformations in research and development settings.

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3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile (C12H17N3O3Si) — chemical structure, CAS 361456-00-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC12Chemical SynthesisHeterocyclic Building BlocksPyridines

01 /Applications

Heterocyclic Synthesis

This compound is utilised as a key intermediate in the construction of novel heterocyclic frameworks. Its pyridine core and reactive functional groups allow for various coupling and modification reactions.

Pharmaceutical Research

It serves as a versatile building block for medicinal chemistry programmes aimed at discovering new therapeutic agents. The molecule's unique substitution pattern can be leveraged to explore structure-activity relationships.

Organic Synthesis

As a functionalized pyridine, it is employed in multi-step organic syntheses to introduce specific structural motifs. The trimethylsilyl ethoxy group can be cleaved under appropriate conditions, offering further synthetic utility.

02 /Properties

Molecular weight	279.37
Empirical formula	C12H17N3O3Si
Assay	97%
Melting point	74-78 °C

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed
H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25-41
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

361456-00-0

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile used for?

This compound is primarily used as a building block in organic synthesis, particularly in the development of novel heterocyclic compounds for pharmaceutical research and other advanced chemical applications.

What are the CAS number and molecular formula?

The CAS number for 3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile is 361456-00-0, and its molecular formula is C12H17N3O3Si.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should this chemical be handled safely?

This compound is classified as Danger, causing serious eye damage and being toxic if swallowed (H301-H318). It requires the use of eyeshields, face shields, gloves, and appropriate respiratory protection (P2 filter). Handle with extreme caution in a well-ventilated area, avoiding all contact and ingestion.

Can Tech Serve Solutions export this product?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile, ensuring compliant international shipping.

How can I request a quote or sample?

To request a quote or sample of 3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile, please contact our sales team through the website or by phone.