3-(N-Boc-amino)phenylboronic acid pinacol ester

CAS 330793-09-4C17H26BNO4Chemical Synthesis

3-(N-Boc-amino)phenylboronic acid pinacol ester (CAS: 330793-09-4; C17H26BNO4; MW: 319.20) is a versatile organoboron compound. It serves as a key building block in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. Its protected amine functionality allows for selective derivatization in the synthesis of complex molecules and pharmaceutical intermediates.

IUPAC: 3-(Boc-amino)phenylboronic acid pinacol ester,tert-Butyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
Synonyms: tert-Butyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

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3-(N-Boc-amino)phenylboronic acid pinacol ester (C17H26BNO4) — chemical structure, CAS 330793-09-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronate EstersBoronate EstersChemical SynthesisOrganometallic Reagents

01 /Applications

Suzuki-Miyaura Cross-Coupling

This boronate ester is extensively employed as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, crucial for constructing biaryl systems found in many active pharmaceutical ingredients.

Synthesis of Pharmaceutical Intermediates

The compound's structure, featuring a protected amine and a boronate ester, makes it ideal for the regioselective synthesis of advanced intermediates. These intermediates are vital in developing novel therapeutic agents.

Organic Synthesis Building Block

As a functionalized arylboronic acid derivative, it offers a stable and reactive moiety for introducing substituted phenyl groups into diverse organic frameworks. Its Boc protecting group ensures controlled reactivity during multi-step syntheses.

02 /Properties

Molecular weight	319.20
Empirical formula	C17H26BNO4
Assay	97%
Melting point	148-153 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

330793-09-4

MDL number

MFCD03789256

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3-(N-Boc-amino)phenylboronic acid pinacol ester primarily used for?

This compound is primarily used as a building block in organic synthesis, especially for Suzuki-Miyaura cross-coupling reactions, and in the synthesis of pharmaceutical intermediates.

What is the CAS number and molecular formula for this product?

The CAS number is 330793-09-4, and the molecular formula is C17H26BNO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product at a minimum assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.

How should 3-(N-Boc-amino)phenylboronic acid pinacol ester be handled safely?

When handling, it is essential to use eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. Please refer to the Safety Data Sheet (SDS) for comprehensive handling information.

Is this chemical a controlled substance?

The provided data does not indicate that this chemical is a controlled substance.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions carefully packs and ships this chemical, adhering to all relevant regulations for domestic and international export of fine chemicals.