3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
3-Methyl-1H-pyrazole-4-boronic acid pinacol ester (CAS 936250-20-3) is an organoboron compound with the formula C10H17BN2O2 and a molecular weight of 208.07 g/mol. This stable boronate ester serves as a valuable building block in organic synthesis. It is particularly useful in cross-coupling reactions, such as Suzuki-Miyaura coupling, for the construction of complex molecules containing the 3-methyl-1H-pyrazol-4-yl moiety.
- IUPAC
- 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
Suzuki-Miyaura Coupling Reagent
This compound is extensively employed as a coupling partner in palladium-catalysed Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the introduction of the 3-methyl-1H-pyrazol-4-yl group into various organic scaffolds.
Pharmaceutical Intermediate Synthesis
The pyrazole motif is prevalent in many biologically active compounds and pharmaceuticals. This boronate ester is a key intermediate for synthesising novel drug candidates and active pharmaceutical ingredients (APIs).
Agrochemical Development
The structural features of this compound can be incorporated into new agrochemical agents. Its use in synthesis allows for the exploration of novel herbicides, insecticides, and fungicides.
Materials Science Research
Organoboron compounds find applications in materials science, including the development of organic light-emitting diodes (OLEDs) and other functional materials. This ester can be used to synthesise novel polymers and molecular materials.
| Molecular weight | 208.07 |
|---|---|
| Empirical formula | C10H17BN2O2 |
| Assay | 97% |
| Melting point | 129-134 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester used for?
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3-Methyl-1H-pyrazole-4-boronic acid pinacol ester is primarily used as a building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, for introducing the 3-methyl-1H-pyrazol-4-yl moiety into target molecules. It finds applications in pharmaceutical and agrochemical research and development, as well as in materials science.
What are the CAS number and molecular formula?
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The CAS number for 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester is 936250-20-3, and its molecular formula is C10H17BN2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester with an assay of 97%. This product is supplied for research and development purposes and is not intended for pharmaceutical, food, or household use. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling precautions for this chemical?
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This compound is a Warning chemical and is classified with H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves, should be worn. Handle in a well-ventilated area, avoiding dust formation. In case of contact, follow the precautionary statements P261 and P305 + P351 + P338.
How is this product packed, shipped, and exported?
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Tech Serve Solutions adheres to stringent packaging protocols to ensure the safe transit of chemicals globally. We are experienced exporters and comply with all relevant international shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester, please contact our sales department via the website or email, providing your specific requirements.
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