3-Methoxy-5-(trifluoromethyl)aniline
3-Methoxy-5-(trifluoromethyl)aniline (CAS 349-55-3), with the molecular formula C8H8F3NO, is a key organic building block. This compound, possessing a molecular weight of 191.15 g/mol, serves as a valuable intermediate in chemical synthesis. Its structure incorporates both an amine and a trifluoromethyl group, making it useful in the development of complex organic molecules, particularly in the pharmaceutical and agrochemical sectors.
- IUPAC
- 5-Methoxy-α,α,α-trifluoro-m-toluidine
- Synonyms
- 5-Methoxy-α,α,α-trifluoro-m-toluidine
Synthesis of Pharmaceutical Intermediates
3-Methoxy-5-(trifluoromethyl)aniline is employed in the synthesis of biologically active compounds. It has been utilized in the development of spleen tyrosine kinase inhibitors, demonstrating its utility in medicinal chemistry research.
Organic Building Block
As a functionalized aniline derivative, this compound serves as a versatile building block in organic synthesis. It allows for the introduction of the methoxy and trifluoromethylphenyl moieties into larger molecular structures.
Chemical Research and Development
Researchers utilise 3-Methoxy-5-(trifluoromethyl)aniline for exploring new synthetic routes and developing novel chemical entities. Its unique structural features are of interest for creating compounds with specific electronic and steric properties.
| Molecular weight | 191.15 |
|---|---|
| Linear formula | CH3OC6H3(CF3)NH2 |
| Assay | 99% |
| Application | 3-Methoxy-5-(trifluoromethyl)aniline was used in the synthesis of spleen tyrosine kinase inhibitors based on the phenylamino pyrimidine thiazole1. |
| Melting point | 50-52 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methoxy-5-(trifluoromethyl)aniline used for?
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3-Methoxy-5-(trifluoromethyl)aniline is used as a chemical intermediate and building block in organic synthesis, notably in the development of pharmaceutical compounds such as spleen tyrosine kinase inhibitors.
What are the CAS number and formula for 3-Methoxy-5-(trifluoromethyl)aniline?
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The CAS number is 349-55-3 and the molecular formula is C8H8F3NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methoxy-5-(trifluoromethyl)aniline with a purity of 99% (assay). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 3-Methoxy-5-(trifluoromethyl)aniline be handled?
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Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation. Avoid breathing dust/fume/gas/mist/vapours/spray. Causes skin irritation, serious eye irritation, and may cause respiratory irritation. Harmful if swallowed, in contact with skin, or if inhaled.
Is 3-Methoxy-5-(trifluoromethyl)aniline a controlled substance?
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Based on the provided data, there is no indication that 3-Methoxy-5-(trifluoromethyl)aniline is a controlled substance.
How is 3-Methoxy-5-(trifluoromethyl)aniline packed and exported?
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As a specialist global supplier, Tech Serve Solutions professionally packs and exports fine chemicals, including 3-Methoxy-5-(trifluoromethyl)aniline, adhering to all relevant shipping and safety regulations for international distribution.
How can I request a quote or sample of 3-Methoxy-5-(trifluoromethyl)aniline?
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To request a quote or sample, please contact our sales team through the website or by phone. Provide the product name and CAS number (349-55-3) for prompt service.
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