(3-Mercaptopropyl)trimethoxysilane
(3-Mercaptopropyl)trimethoxysilane (CAS: 4420-74-0; Formula: HS(CH2)3Si(OCH3)3; MW: 196.34) is a versatile organosilane featuring both a thiol group and trimethoxysilyl functionality. This unique bifunctional nature makes it valuable for surface modification, cross-linking, and as a coupling agent. It finds applications in materials science, microelectronics, and chemical synthesis, enabling the functionalization of surfaces and the creation of advanced nanomaterials.
- IUPAC
- 3-(Trimethoxysilyl)-1-propanethiol
- Synonyms
- 3-(Trimethoxysilyl)-1-propanethiol
Surface Modification
This silane can covalently bond to inorganic surfaces, such as silica or glass, via its trimethoxysilyl groups. The exposed thiol (-SH) end provides a reactive site for further functionalization, enabling tailored surface properties for applications in chromatography, sensors, and biomaterial interfaces.
Self-Assembled Monolayers (SAMs)
It is employed in the formation of self-assembled monolayers on noble metal surfaces. The thiol group strongly adsorbs to gold, while the trimethoxysilyl groups can be used for subsequent layer formation or to anchor the SAM to other substrates, finding use in microelectronics and nanotechnology.
Coupling Agent
As a coupling agent, it can enhance adhesion between inorganic fillers and organic polymers. The trimethoxysilyl end interacts with inorganic materials, and the propyl-thiol chain provides compatibility or reactive sites for organic matrices, improving composite material performance.
Nanomaterial Functionalization
The compound is used to functionalize nanoparticles and quantum dots, imparting specific surface characteristics. The thiol group offers a robust anchor for attaching various organic molecules or for controlling nanoparticle aggregation and dispersion in solution.
| Molecular weight | 196.34 |
|---|---|
| Linear formula | HS(CH2)3Si(OCH3)3 |
| Assay | 95% |
| Form | liquid |
| Boiling point | 213-215 °C(lit.) |
| Density | 1.057 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.444(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H317May cause an allergic skin reaction
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 96 °C / 204.8 °F |
| Transport (UN / ADR) | UN 3082 9/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-43-51/53 |
| Safety statements (S) | 24/25-36/37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (3-Mercaptopropyl)trimethoxysilane used for?
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(3-Mercaptopropyl)trimethoxysilane is primarily used for surface modification, the formation of self-assembled monolayers, as a coupling agent between organic and inorganic materials, and for the functionalization of nanomaterials.
What is the CAS number and formula for (3-Mercaptopropyl)trimethoxysilane?
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The CAS number is 4420-74-0, and the chemical formula is HS(CH2)3Si(OCH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (3-Mercaptopropyl)trimethoxysilane with a minimum assay of 95%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should (3-Mercaptopropyl)trimethoxysilane be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation. This compound is harmful if swallowed, causes skin irritation, and may cause an allergic skin reaction. It is also toxic to aquatic life with long-lasting effects.
Is (3-Mercaptopropyl)trimethoxysilane available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (3-Mercaptopropyl)trimethoxysilane.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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