3-Isopropoxyphenylboronic acid
3-Isopropoxyphenylboronic acid (CAS: 216485-86-8) is an organoboron compound with the molecular formula (CH₃)₂CHOC₆H₄B(OH)₂ and a molar mass of 180.01 g/mol. This aryl boronic acid serves as a key intermediate in organic synthesis. It is widely employed as a reactant in the development of novel pharmaceutical compounds and for creating complex molecular structures in medicinal chemistry research.
- IUPAC
- 3-(1-Methylethoxy)phenylboronic acid,3-(1-Methylethyl)oxyphenylboronic acid,3-Isopropoxybenzeneboronic acid
- Synonyms
- 3-(1-Methylethoxy)phenylboronic acid3-(1-Methylethyl)oxyphenylboronic acid3-Isopropoxybenzeneboronic acid
GSK-3 Inhibitor Synthesis
3-Isopropoxyphenylboronic acid is utilised as a reactant in the synthesis of heteroaryl benzylureas demonstrating glycogen synthase kinase 3 (GSK-3) inhibitory activity.
SMN Protein Modulator Development
This compound is a precursor in the synthesis of modulators designed to influence the survival motor neuron (SMN) protein, a key target in certain neurological research areas.
Cholesteryl Ester Transfer Protein (CETP) Inhibitors
It acts as a reactant in the development of inhibitors targeting cholesteryl ester transfer protein (CETP), relevant for cardiovascular research.
Sphingosine-1-Phosphate Receptor Agonists
3-Isopropoxyphenylboronic acid is employed in the synthesis of selective sphingosine-1-phosphate receptor subtype-1 (S1P1) agonists.
Lamellarin D Analog Synthesis
The boronic acid derivative is used in the creation of cytotoxic open lactone analogues related to Lamellarin D, explored for their biological properties.
| Molecular weight | 180.01 |
|---|---|
| Linear formula | (CH3)2CHOC6H4B(OH)2 |
| Application | Reactant for synthesis of:• Heteroaryl benzylureas with glycogen synthase kinase 3 (GSK-3) inhibitory activity1• Modulators of survival motor neuron (SMN) protein2• Inhibitors of cholesteryl ester transfer protein (CETP)3• Selective sphingosine-1-phosphate receptor subtype-1 agonists4• Cytotoxic open lactone analogs of Lamellarin D5 |
| Melting point | 76-81 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Isopropoxyphenylboronic acid used for?
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3-Isopropoxyphenylboronic acid is primarily used as a reactant in organic synthesis for the development of pharmaceutical intermediates and complex organic molecules, including inhibitors of GSK-3, modulators of SMN protein, CETP inhibitors, and S1P1 receptor agonists.
What are the CAS number and molecular formula for 3-Isopropoxyphenylboronic acid?
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The CAS number for 3-Isopropoxyphenylboronic acid is 216485-86-8. Its linear molecular formula is (CH₃)₂CHOC₆H₄B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Isopropoxyphenylboronic acid with a typical purity of 97% or higher. This product is intended for research and laboratory use. We do not represent it as USP, BP, EP, or pharmaceutical grade unless explicitly stated otherwise.
What are the key safety considerations when handling 3-Isopropoxyphenylboronic acid?
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Handling 3-Isopropoxyphenylboronic acid requires appropriate personal protective equipment, including eyeshields, gloves, and a respirator. It is combustible with a flash point of 110 °C (230 °F). Store in a cool, dry, well-ventilated area away from ignition sources. Consult the Safety Data Sheet (SDS) for comprehensive hazard information.
How is 3-Isopropoxyphenylboronic acid packed and shipped?
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Tech Serve Solutions securely packs and ships 3-Isopropoxyphenylboronic acid globally, adhering to all relevant transport regulations for chemical substances. Packaging is designed to maintain product integrity during transit.
How can I request a sample or quote for 3-Isopropoxyphenylboronic acid?
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To request a sample or a quotation for 3-Isopropoxyphenylboronic acid, please visit the Tech Serve Solutions website or contact our sales department directly with your specific requirements.
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