3-Iodophenylboronic acid
3-Iodophenylboronic acid (CAS: 221037-98-5; Formula: IC6H4B(OH)2; Molar Mass: 247.83) is a key organometallic reagent. As a substituted aryl boronic acid, it serves as a versatile building block in organic synthesis. Its applications span various coupling reactions, including aerobic oxidative coupling, boron-Heck arylation, and N-arylation, making it valuable in the synthesis of complex organic molecules and pharmaceutical intermediates.
Aerobic Oxidative Coupling
3-Iodophenylboronic acid participates in aerobic oxidative coupling reactions with arenes, facilitating the formation of new carbon-carbon bonds under mild conditions.
Boron-Heck Arylation
This compound is employed in boron-Heck arylation reactions with alkenes, a process crucial for synthesizing substituted olefins and related organic structures.
Synthesis of Inhibitors
It serves as a reactant in the synthesis of specific inhibitors, such as those targeting homoserine transacetylase, contributing to medicinal chemistry research.
N-Arylation Reactions
3-Iodophenylboronic acid is utilised in N-arylation reactions, enabling the introduction of aryl groups onto nitrogen atoms in various organic molecules.
| Molecular weight | 247.83 |
|---|---|
| Linear formula | IC6H4B(OH)2 |
| Application | Reactant involved in:• Aerobic oxidative coupling with arenes1• Coupling with acetals2• Synthesis of inhibitors of homoserine transacetylase3• Boron-Heck arylation with alkenes4• N-arylation5• Heck reactions with electrophilic alkenes6 |
| Melting point | 195-197 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Iodophenylboronic acid used for?
+
3-Iodophenylboronic acid is used as a reactant in various organic synthesis applications, including aerobic oxidative coupling with arenes, coupling with acetals, synthesis of inhibitors, boron-Heck arylation with alkenes, N-arylation, and Heck reactions with electrophilic alkenes.
What are the CAS number and formula for 3-Iodophenylboronic acid?
+
The CAS number for 3-Iodophenylboronic acid is 221037-98-5, and its linear formula is IC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-Iodophenylboronic acid typically as a research or technical grade chemical. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated in the product specifications. Please refer to the product data sheet for specific assay information.
How should 3-Iodophenylboronic acid be handled safely?
+
Handling 3-Iodophenylboronic acid requires appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. It is classified as a Warning substance with hazards H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Ensure adequate ventilation and avoid dust formation.
How is 3-Iodophenylboronic acid packed, shipped, and exported?
+
Tech Serve Solutions expertly packs, ships, and exports 3-Iodophenylboronic acid globally, adhering to all relevant regulations for chemical transport. Packaging is designed to maintain product integrity and safety during transit.
How can I request a sample or quote for 3-Iodophenylboronic acid?
+
To request a sample or a quote for 3-Iodophenylboronic acid, please use the 'Request Sample' or 'Request Quote' buttons on our website, or contact our sales team directly with your requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis