3-Bromo-1,1,1-trifluoroacetone
3-Bromo-1,1,1-trifluoroacetone (CAS 431-35-6, CF3COCH2Br) is a halogenated ketone with a molecular weight of 190.95 g/mol. As a versatile building block, it finds application in organic synthesis, particularly in the introduction of trifluoromethyl groups. Its reactivity makes it a valuable reagent for creating complex molecular structures.
- Synonyms
- 431-35-6CF3COCH2Br
Synthesis of Trifluoromethylated Compounds
3-Bromo-1,1,1-trifluoroacetone serves as a key intermediate in the synthesis of various organic molecules incorporating the trifluoromethyl moiety. This includes the preparation of compounds like 3-nonylthio-1,1,1-trifluoropropan-2-one.
Peptide and Alcohol Synthesis
It is employed in the creation of specialised cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone functionalities. Additionally, it is used in the synthesis of perfluoroalkylated trans-allylic alcohols.
Organic Building Block
As a reactive ketone and organobromine compound, 3-Bromo-1,1,1-trifluoroacetone is a valuable building block for a range of chemical transformations and complex molecule construction in research and development.
| Molecular weight | 190.95 |
|---|---|
| Linear formula | CF3COCH2Br |
| Assay | 98% |
| Grade | purum |
| Boiling point | 87 °C/743 mmHg(lit.) |
| Density | 1.839 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.376(lit.) |
| Application | 3-Bromo-1,1,1-trifluoroacetone was used in the synthesis of:• 3-nonylthio-1,1,1-trifluoropropan-2-one1• cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group2• perfluoroalkylated trans-allylic alcohols3 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 5 °C / 41 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34-37 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Bromo-1,1,1-trifluoroacetone used for?
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3-Bromo-1,1,1-trifluoroacetone is used as a building block in organic synthesis, particularly for creating compounds containing trifluoromethyl groups, such as specific ketones, cyclic tetrapeptides, and perfluoroalkylated allylic alcohols.
What is the CAS number and chemical formula for 3-Bromo-1,1,1-trifluoroacetone?
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The CAS number is 431-35-6 and the linear chemical formula is CF3COCH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Bromo-1,1,1-trifluoroacetone with a purity of 98% (grade: purum). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
What are the primary safety hazards associated with 3-Bromo-1,1,1-trifluoroacetone?
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This compound is highly flammable and causes severe skin burns and eye damage. It is classified with GHS symbols indicating a danger signal word. Appropriate personal protective equipment, including face shields, gloves, and respirators, must be used during handling.
How is 3-Bromo-1,1,1-trifluoroacetone packed and exported?
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3-Bromo-1,1,1-trifluoroacetone is packed and exported in accordance with international regulations for hazardous materials. It is shipped as UN 2924, Hazard Class 8(3), Packing Group II.
How can I request a quote or sample for 3-Bromo-1,1,1-trifluoroacetone?
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To request a quote or sample, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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