3-Acetylthiophene
3-Acetylthiophene (CAS: 1468-83-3), a thiophene derivative with the chemical formula C6H6OS, is a valuable building block in organic synthesis. This compound, with a molecular weight of 126.18 g/mol, is characterised by its acetyl group attached to the thiophene ring. It finds utility in the preparation of complex organic molecules, including Schiff's bases and other heterocyclic compounds, serving as a key intermediate in chemical research and development.
- IUPAC
- Methyl-3-thienyl ketone
- Synonyms
- Methyl 3-thienyl ketone

Schiff's Base Synthesis
3-Acetylthiophene has been employed in the synthesis of Schiff's bases, specifically 1-(methylthiophenylidine)-8-naphthylamine, contributing to the development of novel organic compounds.
Heterocyclic Chemistry
As a versatile heterocyclic building block, it is used in the preparation of various thiophene derivatives, such as 1-(thiophen-3-yl)ethanone, facilitating research in medicinal and materials chemistry.
Organic Synthesis Intermediate
This compound serves as a crucial intermediate in multi-step organic synthesis pathways, enabling the construction of more complex molecular architectures in academic and industrial research settings.
| Molecular weight | 126.18 |
|---|---|
| Empirical formula | C6H6OS |
| Assay | 98% |
| Boiling point | 208-210 °C/748 mmHg(lit.) |
| Application | 3-Acetylthiophene was used in the preparation of 1-(methylthiophenylidine)-8-naphthylamine(Schiff′s base)1 and 1-(thiophen-3-yl)ethanone2. |
| Melting point | 57-62 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Acetylthiophene used for?
+
3-Acetylthiophene is used as a building block in organic synthesis, including the preparation of Schiff's bases and other thiophene derivatives. It functions as an intermediate in chemical research.
What are the CAS number and formula for 3-Acetylthiophene?
+
The CAS number for 3-Acetylthiophene is 1468-83-3, and its chemical formula is C6H6OS.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-Acetylthiophene with an assay of 98%. This is a technical grade and TSS does not represent it as USP/BP/EP.
What are the safety considerations when handling 3-Acetylthiophene?
+
Handling 3-Acetylthiophene requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK 2 in Germany.
How is 3-Acetylthiophene packed and shipped?
+
3-Acetylthiophene is available for purchase and export globally by Tech Serve Solutions. Packaging details are available upon request.
How can I request a quote or sample for 3-Acetylthiophene?
+
To request a quote or sample for 3-Acetylthiophene, please contact our sales team through the TSS website or by telephone.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis