3,5-Dimethyl-4-methoxyphenylmagnesium bromide
3,5-Dimethyl-4-methoxyphenylmagnesium bromide (CAS 185416-17-5) is a Grignard reagent primarily used in organic synthesis. This organometallic compound, with a molecular weight of 239.39 g/mol, serves as a valuable nucleophile for forming new carbon-carbon bonds. It is supplied as a solution in Tetrahydrofuran (THF), facilitating its direct use in various chemical transformations. Its reactivity necessitates careful handling under inert conditions.
- Synonyms
- (CH3)2C6H2OCH3MgBr
Carbon-Carbon Bond Formation
As a Grignard reagent, 3,5-Dimethyl-4-methoxyphenylmagnesium bromide readily reacts with electrophiles such as aldehydes, ketones, esters, and epoxides to create new carbon-carbon bonds, a fundamental transformation in organic chemistry.
Synthesis of Aromatic Compounds
This reagent is employed in the synthesis of complex substituted aromatic compounds, where the 3,5-dimethyl-4-methoxyphenyl moiety is incorporated into larger molecular structures.
Pharmaceutical Intermediate Synthesis
It can serve as a building block in the multi-step synthesis of pharmaceutical intermediates, contributing specific structural elements to potential drug candidates.
Advanced Organic Synthesis
Used in academic and industrial research for developing novel synthetic routes and exploring new chemical entities requiring the introduction of its specific aryl group.
| Molecular weight | 239.39 |
|---|---|
| Linear formula | (CH3)2C6H2OCH3MgBr |
| Boiling point | 65 °C(lit.) |
| Density | 0.949 g/mL at 25 °C(lit.) |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Dimethyl-4-methoxyphenylmagnesium bromide used for?
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3,5-Dimethyl-4-methoxyphenylmagnesium bromide is primarily used as a Grignard reagent in organic synthesis for forming carbon-carbon bonds and constructing complex substituted aromatic compounds and pharmaceutical intermediates.
What are the CAS number and formula for this compound?
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The CAS number is 185416-17-5, and the linear formula is (CH₃)₂C₆H₂OCH₃MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a concentration of 0.5 M in THF. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 3,5-Dimethyl-4-methoxyphenylmagnesium bromide be handled safely?
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This compound is highly flammable (flash point -17 °C) and corrosive. It reacts violently with water and can form explosive peroxides. Handle under an inert atmosphere, avoid ignition sources, wear appropriate personal protective equipment (gloves, eye protection), and store at 2-8°C.
How is this chemical packed and shipped?
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This chemical is typically packed and shipped according to UN 2924 8(3) / PGII regulations, reflecting its hazardous nature as a flammable liquid, corrosive material, and toxic substance.
How can I request a sample or quote?
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To request a sample or quote, please contact the Tech Serve Solutions sales team via our website or direct contact information, specifying the product name and CAS number.
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