3,5-Dimethyl-4-methoxyphenylboronic acid

CAS 301699-39-8(CH3)2C6H2OCH3B(OH)2Chemical Synthesis

3,5-Dimethyl-4-methoxyphenylboronic acid (CAS: 301699-39-8) is a substituted aryl boronic acid with the molecular formula (CH3)2C6H2OCH3B(OH)2 and a molecular weight of 180.01 g/mol. This organometallic compound serves as a versatile building block in organic synthesis, primarily utilised in cross-coupling reactions for the preparation of complex molecules. Its specific structure makes it valuable in the synthesis of biologically and pharmacologically active compounds.

IUPAC: 4-Methoxy-3,5-dimethylbenzeneboronic acid,4-Methoxy-3,5-dimethylphenylboronic acid
Synonyms: (CH3)2C6H2OCH3B(OH)24-Methoxy-3,5-dimethylbenzeneboronic acid4-Methoxy-3,5-dimethylphenylboronic acid

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3,5-Dimethyl-4-methoxyphenylboronic acid ((CH3)2C6H2OCH3B(OH)2) — chemical structure, CAS 301699-39-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical SynthesisOrganometallic Reagents

01 /Applications

Biologically Active Molecule Synthesis

3,5-Dimethyl-4-methoxyphenylboronic acid is a key reactant in the preparation of molecules with significant biological and pharmacological activities, contributing to advancements in medicinal chemistry.

Suzuki and Stille Cross-Coupling Reactions

This boronic acid derivative is effectively employed as a coupling partner in Suzuki and Stille cross-coupling reactions, enabling the formation of carbon-carbon bonds critical for complex organic synthesis.

Mizoroki-Heck Arylation

The compound participates in Mizoroki-Heck arylation reactions, facilitating the introduction of aryl groups into organic structures.

Baeyer-Villiger Oxidation

It acts as a reactant in Baeyer-Villiger oxidation processes, a valuable transformation for the synthesis of esters and lactones.

Asymmetric Conjugate Addition

This boronic acid is utilised in Rhodium-catalyzed asymmetric conjugate addition reactions, offering stereoselective synthetic pathways.

02 /Properties

Molecular weight	180.01
Linear formula	(CH3)2C6H2OCH3B(OH)2
Assay	≥95%
Application	Reactant for:• Preparation of biologically and pharmacologically active molecules1,2• Suzuki and Stille cross-coupling reaction3• Mizoroki-Heck arylation4• Baeyer-Villiger oxidation5• Rhodium-catalyzed asymmetric conjugate addition reactions6
Melting point	235-242 °C(lit.)

03 /Identifiers & registry

CAS number

301699-39-8

MDL number

MFCD01114648

PubChem substance

24881736

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is 3,5-Dimethyl-4-methoxyphenylboronic acid used for?

3,5-Dimethyl-4-methoxyphenylboronic acid (CAS: 301699-39-8) is used as a reactant in the preparation of biologically and pharmacologically active molecules, and in various cross-coupling reactions such as Suzuki, Stille, and Mizoroki-Heck arylation, as well as Baeyer-Villiger oxidation and Rhodium-catalyzed asymmetric conjugate addition reactions.

What is the CAS number and chemical formula for 3,5-Dimethyl-4-methoxyphenylboronic acid?

The CAS number is 301699-39-8 and the linear formula is (CH3)2C6H2OCH3B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 3,5-Dimethyl-4-methoxyphenylboronic acid with an assay of ≥95%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.

What are the safety considerations for handling 3,5-Dimethyl-4-methoxyphenylboronic acid?

3,5-Dimethyl-4-methoxyphenylboronic acid has a WGK (German water hazard class) of 3, indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area.