3,5-Dichlorophenylboronic acid
3,5-Dichlorophenylboronic acid (CAS: 67492-50-6) is a disubstituted aryl boronic acid with the linear formula Cl2C6H3B(OH)2 and a molecular weight of 190.82 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions. Its applications span the creation of complex organic molecules, making it an important reagent for researchers in pharmaceuticals and materials science.
- IUPAC
- (3,5-Dichlorophenyl)dihydroxyborane,3,5-Dichlorobenzeneboronic acid
- Synonyms
- (3,5-Dichlorophenyl)dihydroxyborane3,5-Dichlorobenzeneboronic acid
Suzuki-Miyaura Cross-Coupling
3,5-Dichlorophenylboronic acid is a key reactant in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with aryl and vinyl halides.
Trifluoromethylation Reactions
This boronic acid derivative can be employed in trifluoromethylation processes, introducing CF3 groups into organic structures for specialised applications.
Aromatic Carbenoid Insertion
It participates in intramolecular aromatic carbenoid insertion reactions of biaryldiazoacetates, facilitating complex molecular syntheses.
Synthesis of Aromatic Nitriles
The compound is utilised in cyanation reactions, serving as a precursor for the synthesis of functionalised aromatic nitriles.
Functionalised Boronic Acid Synthesis
It is involved in lithiation reactions of dihalophenyl dioxazaborocines, a route to synthesise specific functionalised dihalophenyl boronic acids.
| Molecular weight | 190.82 |
|---|---|
| Linear formula | Cl2C6H3B(OH)2 |
| Assay | 98% |
| Application | Reactant involved in:• Suzuki-Miyaura cross-coupling1,2• Trifluoromethylation3• Intramolecular aromatic carbenoid insertion of biaryldiazoacetates4• Cyanation for the synthesis of aromatic nitriles5• Lithiation of dihalophenyl dioxazaborocines for synthesis of functionalized dihalophenyl boronic acid6 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Dichlorophenylboronic acid used for?
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3,5-Dichlorophenylboronic acid is primarily used as a reactant in organic synthesis, notably in Suzuki-Miyaura cross-coupling reactions, trifluoromethylation, intramolecular aromatic carbenoid insertion, and the synthesis of aromatic nitriles and functionalised boronic acids.
What are the CAS number and formula for 3,5-Dichlorophenylboronic acid?
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The CAS number is 67492-50-6, and the linear formula is Cl2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Dichlorophenylboronic acid with an assay of 98%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should 3,5-Dichlorophenylboronic acid be handled?
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3,5-Dichlorophenylboronic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is 3,5-Dichlorophenylboronic acid packed and shipped?
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3,5-Dichlorophenylboronic acid is carefully packed to ensure safe transit and is available for domestic and international export. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of 3,5-Dichlorophenylboronic acid, please contact our sales team through the website or by phone. Our experts will be pleased to assist you.
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