3,3-Dimethylacryloyl chloride
3,3-Dimethylacryloyl chloride (CAS: 3350-78-5) is an organic acid halide with a molar mass of 118.56 g/mol. This reactive compound serves as a valuable building block in organic synthesis. It is primarily utilised in the preparation of various chemical intermediates and specialised organic molecules, contributing to advancements in chemical research and development.
- IUPAC
- 3-Methyl-2-butenoyl chloride,3-Methylcrotonoyl chloride,Senecioyl chloride
- Synonyms
- 3-Methyl-2-butenoyl chloride3-Methylcrotonoyl chlorideSenecioyl chloride
Synthesis of Quinolone Derivatives
3,3-Dimethylacryloyl chloride is employed in condensation reactions with anilines to produce substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one derivatives.
Peptide Synthesis
It can be used for the acylation of amino acids, as demonstrated in the synthesis of N-(3,3-Dimethylacryloyl)-(S)-leucine methyl ester.
Organic Building Block
As a versatile carbonyl compound, it functions as a key intermediate in the construction of more complex organic structures.
| Molecular weight | 118.56 |
|---|---|
| Linear formula | (CH3)2C=CHCOCl |
| Assay | 97% |
| Boiling point | 145-147 °C(lit.) |
| Density | 1.065 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.476(lit.) |
| Contains / stabiliser | 400 ppm phenothiazine as inhibitor |
| Application | 3,3-Dimethylacryloyl chloride was used in the synthesis of:• substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one via condensation with aniline1• N-(3,3-Dimethylacryloyl)-(S)-leucine methyl ester2 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 51 °C / 123.8 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-36/37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,3-Dimethylacryloyl chloride used for?
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3,3-Dimethylacryloyl chloride is used as a building block in organic synthesis, including the preparation of substituted quinolinone derivatives and acylation of amino acids.
What are the CAS number and formula for 3,3-Dimethylacryloyl chloride?
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The CAS number is 3350-78-5, and its linear formula is (CH3)2C=CHCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,3-Dimethylacryloyl chloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for 3,3-Dimethylacryloyl chloride?
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3,3-Dimethylacryloyl chloride is a flammable liquid and causes severe skin burns and eye damage, and may cause respiratory irritation (H226, H314, H335). It reacts violently with water. Handle with appropriate personal protective equipment, including gloves, goggles, and respiratory protection, in a well-ventilated area.
How is 3,3-Dimethylacryloyl chloride shipped and exported?
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3,3-Dimethylacryloyl chloride is shipped as UN 2920, Hazard Class 3(8), Packing Group II. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample?
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Please contact our sales team via the website or by phone to request a quote or a sample of 3,3-Dimethylacryloyl chloride.
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