(2R)-(−)-Glycidyl tosylate
(2R)-(−)-Glycidyl tosylate (CAS: 113826-06-5, Formula: C10H12O4S) is a chiral epoxide with a molecular weight of 228.26 g/mol. Supplied by Tech Serve Solutions with an assay of 98%, this compound serves as a valuable building block in asymmetric synthesis. Its enantiomerically pure nature makes it particularly useful for constructing complex chiral molecules in organic synthesis and pharmaceutical research, requiring careful handling due to its hazardous properties.
- IUPAC
- (R)-(−)-Glycidyl p-toluenesulfonate,(R)-(−)-Glycidyl tosylate,(R)-(−)-Oxirane-2-methanol p-toluenesulfonate salt
- Synonyms
- (R)-(−)-Glycidyl p-toluenesulfonate(R)-(−)-Glycidyl tosylate(R)-(−)-Oxirane-2-methanol p-toluenesulfonate salt
Enantioselective Synthesis
This chiral epoxide is instrumental in the enantioselective synthesis of various complex molecules. It has been notably used in the synthesis of chiral pyrido[3,2-b]oxazines, demonstrating its utility in creating stereochemically defined compounds.
Chiral Building Block
As a key chiral building block, (2R)-(−)-Glycidyl tosylate facilitates the introduction of specific stereochemistry into target molecules. Its epoxide ring and tosylate leaving group offer versatile reactivity for further functionalization in multi-step syntheses.
Organic Synthesis Reagent
In general organic synthesis, this compound acts as a versatile electrophile. Its reactivity profile allows for nucleophilic ring-opening reactions, leading to a variety of chiral alcohols and derivatives with controlled stereochemistry.
| Molecular weight | 228.26 |
|---|---|
| Empirical formula | C10H12O4S |
| Assay | 98% |
| Storage temperature | 2-8°C |
| Application | Used in the first enantioselective synthesis of (R)- and (S)-4-acetyl-3-(hydroxymethyl)-3,4-dihydro-2H-pyrido[3,2-b]oxazines.1 |
| Melting point | 46-49 °C(lit.) |
Hazard statements
- H318Causes serious eye damage
- H334May cause allergy or asthma symptoms if inhaled
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 45-41-43-51/53-68 |
| Safety statements (S) | 53-26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2R)-(−)-Glycidyl tosylate used for?
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This compound is primarily used as a chiral building block in asymmetric synthesis, particularly in the enantioselective synthesis of complex organic molecules and pharmaceutical intermediates. It has been employed in constructing chiral pyrido[3,2-b]oxazines.
What is the CAS number and formula for (2R)-(−)-Glycidyl tosylate?
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(2R)-(−)-Glycidyl tosylate has the CAS number 113826-06-5 and the molecular formula C10H12O4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (2R)-(−)-Glycidyl tosylate with an assay of 98%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling precautions for (2R)-(−)-Glycidyl tosylate?
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This compound is classified as Danger and carries hazard statements H318 (Causes serious eye damage) and H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled), and H350 (May cause cancer). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., full-face particle respirator type N100), is mandatory. Always consult the Safety Data Sheet (SDS) before handling.
How is (2R)-(−)-Glycidyl tosylate packed, shipped, and exported?
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Information regarding specific packing and shipping methods for UN 3077, Class 9, PGIII shipments can be provided upon request. Tech Serve Solutions is an experienced global exporter of fine chemicals.
How can I request a sample or quote for (2R)-(−)-Glycidyl tosylate?
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To request a sample or a quote, please contact our sales team through the website or via direct inquiry, providing your specific requirements and delivery details.
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