2-(Phenylthio)ethanol
2-(Phenylthio)ethanol (CAS 699-12-7) is an organic sulfur compound with the formula C6H5SCH2CH2OH and a molar mass of 154.23 g/mol. This chemical serves as a valuable building block in organic synthesis. It is particularly noted for its utility in the preparation of heterocyclic compounds such as indole, benzofuran, and benzothiophene derivatives, as well as in specialised applications involving nucleotide modifications.
- IUPAC
- 2-Hydroxyethyl phenyl sulfide
- Synonyms
- 2-Hydroxyethyl phenyl sulfide
Synthesis of Heterocyclic Compounds
2-(Phenylthio)ethanol is employed as a precursor in the synthesis of important heterocyclic frameworks including indole, benzofuran, and benzothiophene ring systems. This application leverages the reactivity of the phenylthio group and the hydroxyl functionality.
Nucleotide Chemistry
This compound has been used to temporarily mask the thymine residue during the synthesis of modified thymidine derivatives. This strategy is crucial for controlling regioselectivity in complex nucleotide modifications.
Preparation of Nitriles
It serves as a starting material in the preparation of specific nitrile compounds, such as 4-[2-(phenylthio)ethoxy]phthalonitrile. This highlights its role in constructing more complex organic molecules.
| Molecular weight | 154.23 |
|---|---|
| Linear formula | C6H5SCH2CH2OH |
| Assay | 99% |
| Boiling point | 115-116 °C/2 mmHg(lit.) |
| Density | 1.143 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.592(lit.) |
| Application | 2-(Phenylthio)ethanol has been used:• in the synthesis of indole, benzofuran and benzothiophene1• for temporary masking of the thymine residue during the synthesis of sugar modified thymidine derivatives2• in the preparation of 4-[2-(phenylthio)ethoxy]phthalonitrile3 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Phenylthio)ethanol used for?
+
2-(Phenylthio)ethanol is used as a building block in organic synthesis, notably for the preparation of indole, benzofuran, and benzothiophene derivatives, and for temporary masking of the thymine residue in the synthesis of modified thymidine derivatives.
What are the CAS number and chemical formula for 2-(Phenylthio)ethanol?
+
The CAS number for 2-(Phenylthio)ethanol is 699-12-7, and its chemical formula is C6H5SCH2CH2OH.
What grade and purity does Tech Serve Solutions supply for 2-(Phenylthio)ethanol?
+
Tech Serve Solutions supplies 2-(Phenylthio)ethanol with an assay of 99%. This is a technical/research grade product, and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling considerations for 2-(Phenylthio)ethanol?
+
2-(Phenylthio)ethanol has a flash point of 113 °C (235.4 °F). Appropriate personal protective equipment includes eyeshields, gloves, and suitable respiratory protection (half-mask respirator EU/US, or multi-purpose combination respirator cartridge US). It is classified with WGK Germany 3.
How is 2-(Phenylthio)ethanol packed and shipped by TSS?
+
Tech Serve Solutions is a global supplier and exporter of fine chemicals and laboratory reagents, shipping products worldwide in compliance with international regulations.
How can I request a sample or quote for 2-(Phenylthio)ethanol?
+
To request a sample or a quote for 2-(Phenylthio)ethanol, please contact the TSS sales department through our website or by calling our customer service line.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis