2-Nitrophenylacetonitrile
2-Nitrophenylacetonitrile (CAS: 610-66-2, Formula: O2NC6H4CH2CN) is a key organic building block with a molecular weight of 162.15 g/mol. This compound serves as a valuable intermediate in chemical synthesis, particularly for nitrogen-containing heterocyclic structures. Its applications span the creation of complex molecules, making it an essential reagent for researchers and manufacturers in the fine chemical and pharmaceutical sectors.
Synthesis of α-Carbolines
2-Nitrophenylacetonitrile is utilized in the one-pot synthesis of 2 or 2,4-substituted α-carbolines. This reaction typically involves α,β-unsaturated ketones as co-reactants.
Strychnine Synthesis Intermediate
This compound has been employed as a precursor in the synthetic pathways leading to the complex alkaloid, strychnine.
Organic Synthesis Reagent
As a versatile building block, 2-Nitrophenylacetonitrile facilitates the construction of various organic molecules, contributing to advances in chemical research and development.
| Molecular weight | 162.15 |
|---|---|
| Linear formula | O2NC6H4CH2CN |
| Assay | 98% |
| Application | 2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones1. It was used in the synthesis of strychnine2. |
| Melting point | 82-85 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Nitrophenylacetonitrile used for?
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2-Nitrophenylacetonitrile is primarily used as a building block in organic synthesis, notably for the preparation of α-carbolines and as an intermediate in the synthesis of strychnine.
What are the CAS number and chemical formula for 2-Nitrophenylacetonitrile?
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The CAS number for 2-Nitrophenylacetonitrile is 610-66-2, and its chemical formula is O2NC6H4CH2CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Nitrophenylacetonitrile with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-Nitrophenylacetonitrile be handled safely?
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Handle 2-Nitrophenylacetonitrile with appropriate personal protective equipment, including a dust mask (type N95 recommended), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation. It is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation.
Does TSS export 2-Nitrophenylacetonitrile?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Nitrophenylacetonitrile.
How can I request a sample or quote for 2-Nitrophenylacetonitrile?
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To request a sample or quote for 2-Nitrophenylacetonitrile, please contact our sales team through the website or via direct inquiry.
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