2-Methylpiperidine
2-Methylpiperidine (CAS: 109-05-7), a cyclic secondary amine with the formula C6H13N and a molecular weight of 99.17 g/mol, serves as a key heterocyclic building block. It is utilised as a reactant in diverse chemical syntheses, including C-2 arylation of piperidines and the preparation of complex molecules like azepan-4-ones and gefitinib analogues.
- IUPAC
- α-Pipecoline,2-Pipecoline
C-2 Arylation of Piperidines
2-Methylpiperidine acts as a reactant in directed transition metal-catalyzed sp3 C-H activation for the arylation of piperidine scaffolds.
Synthesis of Azepan-4-ones
It is employed in a two-step annulation process to synthesise azepan-4-one derivatives, valuable intermediates in organic chemistry.
Preparation of Heterocyclic Compounds
This compound facilitates the synthesis of various heterocyclic structures, including 2-aminobenzoxazoles and potentially contributing to the development of novel pharmaceutical agents.
Development of Pharmaceutical Intermediates
2-Methylpiperidine is a precursor in the synthesis of compounds such as corticotropin-releasing factor receptor type 1 antagonists and gefitinib analogues with observed anti-tumour activity.
| Molecular weight | 99.17 |
|---|---|
| Empirical formula | C6H13N |
| Assay | 98% |
| Boiling point | 118-119 °C/753 mmHg(lit.) |
| Density | 0.844 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.445(lit.) |
| Application | Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation1Reactant for synthesis of:• Azepan-4-ones via two step [5+2] annulation2• 2-Aminobenzoxazoles3• Unsymmetrically substituted ureas4• Corticotropin-releasing factor receptor type 1 antagonists5• Gefitinib analogues with anti-tumor activity6 |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 10 °C / 50 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-22-37/38-41 |
| Safety statements (S) | 16-26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methylpiperidine used for?
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2-Methylpiperidine is used as a reactant in chemical synthesis, notably for C-2 arylation of piperidines, synthesis of azepan-4-ones, 2-aminobenzoxazoles, unsymmetrically substituted ureas, corticotropin-releasing factor receptor type 1 antagonists, and gefitinib analogues.
What is the CAS number and formula for 2-Methylpiperidine?
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The CAS number for 2-Methylpiperidine is 109-05-7, and its chemical formula is C6H13N.
What grade and purity does Tech Serve Solutions supply for 2-Methylpiperidine?
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Tech Serve Solutions supplies 2-Methylpiperidine with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety hazards associated with 2-Methylpiperidine?
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2-Methylpiperidine is a flammable liquid and vapour (H225) and is harmful if swallowed (H302). It causes skin irritation (H315), serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used.
How is 2-Methylpiperidine typically packed and exported?
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2-Methylpiperidine is supplied in laboratory quantities and can be packed and exported in compliance with international shipping regulations for hazardous materials.
How can I request a quote or sample of 2-Methylpiperidine?
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To request a quote or sample of 2-Methylpiperidine, please contact our sales team through the website or by phone.
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