2-Methylindoline
2-Methylindoline (CAS: 6872-06-6), a heterocyclic compound with the formula C9H11N and a molecular weight of 133.19 g/mol, is a valuable building block in chemical synthesis. It is primarily utilised as a reactant in the preparation of various complex molecules, including pharmaceutical intermediates, receptor antagonists, and fluorescent dyes. Its utility spans diverse fields, from medicinal chemistry to materials science.
- IUPAC
- α-Methyldihydroindole,2,3-Dihydro-2-methylindole,2-Methyl-2,3-dihydroindole,NSC 65598
- Synonyms
- 2,3-Dihydro-2-methylindolealpha-Methyldihydroindole2,3-Dihydro-2-methyl-1H-indoleNSC 65598
Pharmaceutical Intermediate Synthesis
2-Methylindoline serves as a key reactant in the synthesis of pharmacologically active compounds, such as inhibitors of NOD1-induced nuclear factor-κB activation, norepinephrine reuptake inhibitors, and dopamine receptor antagonists. It is also a precursor for the diuretic agent indapamide.
Development of Receptor Antagonists
This compound is employed in the development of selective antagonists for various receptors, including MT2-selective melatonin receptor antagonists and protease-activated receptor-1 antagonists, which are significant targets in drug discovery.
Materials Science Applications
2-Methylindoline is utilised in the preparation of red fluorescent dyes suitable for organic light-emitting diodes (OLEDs), contributing to advancements in display and lighting technologies.
Synthesis of Antitumor Agents
The chemical structure of 2-Methylindoline makes it a useful building block for the synthesis of novel antitumor agents, representing its potential contribution to cancer research and therapy.
| Molecular weight | 133.19 |
|---|---|
| Empirical formula | C9H11N |
| Assay | 98% |
| Boiling point | 228-229 °C(lit.) |
| Density | 1.023 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.569(lit.) |
| Application | Reactant for preparation of:• Inhibitors of NOD1-induced nuclear factor-κB activation1• Red fluorescent dyes for organic light-emitting diodes2• Norepinephrine reuptake inhibitors3• MT2-selective melatonin receptor antagonists4• Protease-activated receptor-1 antagonists5• Diuretic agent indapamide6• Dopamine D2/D4 receptor antagonists7• Antitumor agents8 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methylindoline used for?
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2-Methylindoline is used as a reactant in the synthesis of inhibitors of NOD1-induced nuclear factor-κB activation, red fluorescent dyes for OLEDs, norepinephrine reuptake inhibitors, MT2-selective melatonin receptor antagonists, protease-activated receptor-1 antagonists, the diuretic agent indapamide, dopamine D2/D4 receptor antagonists, and antitumor agents.
What are the CAS number and formula for 2-Methylindoline?
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The CAS number for 2-Methylindoline is 6872-06-6, and its empirical formula is C9H11N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methylindoline with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 2-Methylindoline be handled safely?
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2-Methylindoline is classified with GHS07 symbol and a Warning signal word. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used when handling this chemical. Ensure good ventilation.
Can Tech Serve Solutions export 2-Methylindoline?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Methylindoline.
How can I request a sample or quote for 2-Methylindoline?
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Please contact our sales team or use the online enquiry form on our website to request a sample or a quote for 2-Methylindoline.
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