2-Methyl-3-indoleacetic acid
2-Methyl-3-indoleacetic acid (CAS: 1912-43-2) is a heterocyclic organic compound with the molecular formula C11H11NO2 and a molecular weight of 189.21 g/mol. This white to off-white solid serves as a valuable building block in organic synthesis. It is primarily utilised as a reactant in the preparation of various indomethacin analogs and other complex organic molecules, including potential antidepressant and anticonvulsant agents.
Preparation of N-Methyl-N-[[(nitrophenyl)sulfonyl]oxy]indoleacetamide Derivatives
This compound acts as a key reactant in synthesising specific N-methyl-N-substituted indoleacetamide derivatives, which are important intermediates in medicinal chemistry research.
Synthesis of Indomethacin Analogs
2-Methyl-3-indoleacetic acid is employed in the preparation of structural analogs of the anti-inflammatory drug indomethacin, facilitating the exploration of related therapeutic agents.
Coupling Reactions with Diazomethane
It is utilised as a reactant in coupling reactions involving diazomethane, a fundamental transformation in organic synthesis for extending carbon chains or forming specific functional groups.
Development of Antidepressant/Anticonvulsant Agents
The compound serves as a precursor for synthesising novel (methylindolyl)methyltriazolethiones and (methylindolyl)methylthiazolylamines, investigated for their potential antidepressant and anticonvulsant activities.
| Molecular weight | 189.21 |
|---|---|
| Empirical formula | C11H11NO2 |
| Assay | 98% |
| Application | • Reactant for preparation of N-methyl-N-[[(nitrophenyl)sulfonyl]oxy]indoleacetamide derivatives1• Reactant for preparation of indomethacin analogs and derivatives2• Reactant for coupling reaction with diazomethane3• Reactant for prepnaration of (methylindolyl)methyltriazolethiones and (methylindolyl)methylthiadiazolylamines as antidepressant/anticonvulsant agents4 |
| Melting point | 205 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methyl-3-indoleacetic acid used for?
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2-Methyl-3-indoleacetic acid is primarily used as a reactant in organic synthesis for preparing indomethacin analogs, N-methyl-N-substituted indoleacetamides, and heterocyclic compounds with potential antidepressant and anticonvulsant activities.
What is the CAS number and formula for 2-Methyl-3-indoleacetic acid?
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The CAS number is 1912-43-2 and the empirical formula is C11H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methyl-3-indoleacetic acid with a minimum purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-Methyl-3-indoleacetic acid be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter if airborne exposure is possible. Consult the Safety Data Sheet for detailed handling procedures.
Is 2-Methyl-3-indoleacetic acid a controlled substance?
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The provided data does not indicate that 2-Methyl-3-indoleacetic acid is a controlled substance.
How is 2-Methyl-3-indoleacetic acid packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports fine chemicals globally, adhering to all necessary regulations for safe and secure transport.
How can I request a sample or quote for 2-Methyl-3-indoleacetic acid?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (1912-43-2).
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