2-Methyl-1-naphthylmagnesium bromide
2-Methyl-1-naphthylmagnesium bromide (CAS: 21450-90-8) is an organometallic compound with the linear formula C10H6CH3MgBr and a molecular weight of 245.40 g/mol. Supplied as a 0.25 M solution in THF, this Grignard reagent is highly reactive and finds application in organic synthesis, particularly for introducing the 2-methyl-1-naphthyl group into various molecular structures. Its reactivity necessitates careful handling under inert conditions.
Organic Synthesis Reagent
As a Grignard reagent, 2-Methyl-1-naphthylmagnesium bromide is a powerful nucleophile used for carbon-carbon bond formation. It reacts with electrophiles such as aldehydes, ketones, esters, and epoxides to create more complex organic molecules.
Introduction of Naphthyl Moiety
This compound serves as a convenient source for the 2-methyl-1-naphthyl group. It is employed in the synthesis of various derivatives and functionalised aromatic compounds containing this specific structural unit.
Pharmaceutical Intermediate Synthesis
It can be utilised in multi-step synthetic routes towards complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs) where the 2-methyl-1-naphthyl scaffold is a required structural element.
Material Science Research
Organometallic reagents like this are sometimes explored in material science for the synthesis of novel organic materials or polymers with specific electronic or optical properties.
| Molecular weight | 245.40 |
|---|---|
| Linear formula | C10H6CH3MgBr |
| Boiling point | 65 °C(lit.) |
| Density | 0.921 g/mL at 25 °C(lit.) |
| Concentration | 0.25 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37/38-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methyl-1-naphthylmagnesium bromide primarily used for?
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2-Methyl-1-naphthylmagnesium bromide is primarily used as a Grignard reagent in organic synthesis for the formation of carbon-carbon bonds and the introduction of the 2-methyl-1-naphthyl group into target molecules.
What is the CAS number and formula for 2-Methyl-1-naphthylmagnesium bromide?
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The CAS number is 21450-90-8 and the linear formula is C10H6CH3MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methyl-1-naphthylmagnesium bromide at a concentration of 0.25 M in THF. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
How should 2-Methyl-1-naphthylmagnesium bromide be handled safely?
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Danger! This compound is flammable (Flash Point -17 °C), reacts violently with water, causes severe skin burns and eye damage, and may cause respiratory irritation. It may also form explosive peroxides. Handle under an inert atmosphere in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment.
How is 2-Methyl-1-naphthylmagnesium bromide packed and shipped?
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This chemical is packed and shipped according to UN 2924, Hazard Class 8(3), Packing Group II regulations, reflecting its hazardous nature. TSS is a specialist global supplier and exporter.
How can I request a quote or sample?
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To request a quote or sample, please contact the TSS sales team via our website or direct email, providing your specific requirements and shipping details.
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