2-Methoxy-5-methylphenylboronic acid
2-Methoxy-5-methylphenylboronic acid (CAS: 127972-00-3) is an organoboron compound with the formula C6H3CH3OCH3B(OH)2 and a molecular weight of 165.98 g/mol. It serves as a valuable reactant in various synthetic organic chemistry applications, including coupling reactions and the preparation of complex molecules. This aryl boronic acid is a key intermediate in the synthesis of pharmaceutical candidates and other fine chemicals, offered by TSS with a typical assay of ≥95%.
- IUPAC
- 5-Methyl-2-methoxyphenylboronic acid
Coupling Reactions
This boronic acid is utilised as a reactant in various coupling reactions, notably in Suzuki-Miyaura cross-coupling methodologies, facilitating the formation of carbon-carbon bonds.
Pharmaceutical Intermediate Synthesis
It is employed in the preparation of selective quinazolinyl-phenol inhibitors of CHK1, which are investigated as potential antitumour agents and radioprotectants.
Asymmetric Catalysis
The compound participates in Rh-catalyzed asymmetric arylation of aldehydes and stereoselective hydroarylation reactions, contributing to enantioselective synthesis.
| Molecular weight | 165.98 |
|---|---|
| Linear formula | C6H3CH3OCH3B(OH)2 |
| Assay | ≥95% |
| Application | Reactant for:• Coupling reactions1• Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants2• Rh-catalyzed asymmetric arylation of aldehydes3• Stereoselective hydroarylation reactions4• Suzuki-Miyaura cross-coupling5,6 |
| Melting point | 92-97 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxy-5-methylphenylboronic acid used for?
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2-Methoxy-5-methylphenylboronic acid is used as a reactant in coupling reactions, including Suzuki-Miyaura cross-coupling, and in the synthesis of potential pharmaceutical agents like CHK1 inhibitors and in asymmetric catalysis.
What are the CAS number and molecular formula for 2-Methoxy-5-methylphenylboronic acid?
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The CAS number is 127972-00-3, and the linear molecular formula is C6H3CH3OCH3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methoxy-5-methylphenylboronic acid with a purity of ≥95%. We do not represent this product as meeting USP, BP, EP, or any other pharmacopoeial standards.
What are the safety considerations when handling 2-Methoxy-5-methylphenylboronic acid?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3, indicating it is hazardous.
How is 2-Methoxy-5-methylphenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions ensures secure and compliant packing for all its chemical products, including 2-Methoxy-5-methylphenylboronic acid, for global export.
How can I request a sample or quote for 2-Methoxy-5-methylphenylboronic acid?
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To request a sample or a quote, please contact our sales team through the website or by direct inquiry, providing the product name and CAS number.
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