2-Isopropoxyphenylboronic acid
2-Isopropoxyphenylboronic acid (CAS: 138008-97-6; Formula: C6H4OCH(CH3)2B(OH)2; MW: 180.01) is a boronic acid derivative widely employed as a reactant in palladium-catalyzed cross-coupling reactions. Its primary application lies in facilitating Suzuki-Miyaura couplings, a vital synthetic methodology for forming carbon-carbon bonds. This compound is a valuable building block in organic synthesis for the construction of complex molecules, particularly within pharmaceutical and materials science research.
- IUPAC
- 2-(Propan-2-yloxy)phenylboronic acid,2-Isopropoxybenzeneboronic acid
- Synonyms
- 2-(Propan-2-yloxy)phenylboronic acid2-Isopropoxybenzeneboronic acid
Suzuki Arylation
2-Isopropoxyphenylboronic acid serves as a key coupling partner in Suzuki arylation reactions. This methodology is essential for the synthesis of biaryl compounds and other structures featuring new carbon-carbon bonds.
Palladium-Catalyzed Suzuki-Miyaura Reaction
This compound is a frequently used reagent in the palladium-catalyzed Suzuki-Miyaura reaction. It enables the efficient coupling of aryl or vinyl halides with organoboron compounds, forming substituted aromatic systems.
Organic Synthesis Building Block
As a functionalized aryl boronic acid, it is a versatile intermediate for constructing more complex organic molecules. Its utility spans across various research and development applications in medicinal chemistry and materials science.
| Molecular weight | 180.01 |
|---|---|
| Linear formula | C6H4OCH(CH3)2B(OH)2 |
| Boiling point | 199 °C(lit.) |
| Density | 1.075 g/mL at 25 °C(lit.) |
| Refractive index | n20/D >1.5090(lit.) |
| Application | Reactant for:• Suzuki arylation1• Palladium-catalyzed Suzuki-Miyaura reaction2,3,4 |
| Melting point | 30-35 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Isopropoxyphenylboronic acid used for?
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2-Isopropoxyphenylboronic acid is primarily used as a reactant in Suzuki arylation and palladium-catalyzed Suzuki-Miyaura reactions for the synthesis of complex organic molecules.
What are the CAS number and chemical formula for 2-Isopropoxyphenylboronic acid?
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The CAS number is 138008-97-6 and the chemical formula is C6H4OCH(CH3)2B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Isopropoxyphenylboronic acid with a purity typically greater than 97%. This product is supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should 2-Isopropoxyphenylboronic acid be handled?
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Handle 2-Isopropoxyphenylboronic acid with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation with a half-mask respirator. Avoid contact with skin and eyes, and do not inhale dust or vapours. It is classified as causing skin irritation, serious eye irritation, and may cause respiratory irritation.
How is 2-Isopropoxyphenylboronic acid shipped?
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2-Isopropoxyphenylboronic acid is carefully packaged and exported by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical compounds.
How can I request a quote or sample for 2-Isopropoxyphenylboronic acid?
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To request a quote or a sample of 2-Isopropoxyphenylboronic acid, please contact our sales team through the website or by phone, providing your specific requirements.
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