2-Fluoro-6-methoxyphenylboronic acid

CAS 78495-63-3FC6H3(OCH3)B(OH)2Chemical Synthesis

2-Fluoro-6-methoxyphenylboronic acid (CAS: 78495-63-3; Formula: FC6H3(OCH3)B(OH)2; MW: 169.95) is a disubstituted aryl boronic acid. It serves as a valuable building block in organic synthesis, particularly for the preparation of complex molecules through reactions like the Suzuki cross-coupling. This compound is instrumental in the development of novel pharmaceuticals, including modulators of GABAA receptors and inhibitors of the checkpoint kinase Wee1, underscoring its significance in medicinal chemistry research and development.

IUPAC: 2-Fluoro-6-methyloxyphenylboronic acid,6-Fluoro-2-methoxyphenylboronic acid

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2-Fluoro-6-methoxyphenylboronic acid (FC6H3(OCH3)B(OH)2) — chemical structure, CAS 78495-63-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki Cross-Coupling Reactions

Utilised as a key reactant in palladium-catalysed Suzuki cross-coupling reactions to form new carbon-carbon bonds. This is a fundamental transformation in the synthesis of biaryl compounds and complex organic structures.

Pharmaceutical Intermediate

Serves as a precursor in the synthesis of functionally selective allosteric modulators of GABAA receptors. It is also employed in the preparation of inhibitors targeting the checkpoint kinase Wee1.

Organic Synthesis Building Block

A versatile organoboron compound used in various synthetic methodologies for constructing intricate molecular architectures relevant to medicinal chemistry and materials science.

02 /Properties

Molecular weight	169.95
Linear formula	FC6H3(OCH3)B(OH)2
Application	Reactant for:• Preparation of functionally selective allosteric modulators of GABAA receptors1• Suzuki cross-coupling reaction2,3• Preparation of inhibitors of the checkpoint kinase Wee14
Melting point	120-125 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

78495-63-3

MDL number

MFCD02179483

PubChem substance

24873655

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-Fluoro-6-methoxyphenylboronic acid primarily used for?

2-Fluoro-6-methoxyphenylboronic acid is primarily used as a reactant in Suzuki cross-coupling reactions and as an intermediate in the synthesis of pharmaceutical compounds, such as modulators of GABAA receptors and Wee1 kinase inhibitors.

What are the CAS number and chemical formula for 2-Fluoro-6-methoxyphenylboronic acid?

The CAS number is 78495-63-3 and the chemical formula is FC6H3(OCH3)B(OH)2.

What grade and purity does Tech Serve Solutions supply for 2-Fluoro-6-methoxyphenylboronic acid?

Tech Serve Solutions supplies 2-Fluoro-6-methoxyphenylboronic acid as a research or technical grade chemical. We do not represent it as USP, BP, or EP grade.

What are the safety considerations when handling 2-Fluoro-6-methoxyphenylboronic acid?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK Germany rating of 3, indicating it is hazardous to water.