2-Ethyl-3-methoxypyrazine
2-Ethyl-3-methoxypyrazine (CAS: 25680-58-4, Formula: C7H10N2O) is a heterocyclic organic compound with a molecular weight of 138.17 g/mol. This compound is recognised for its characteristic aroma and is utilised in analytical chemistry. It is frequently employed as an internal standard in gas chromatography for the precise determination of specific volatile compounds, contributing to accurate flavour and odour analysis.

Internal Standard in Chromatography
2-Ethyl-3-methoxypyrazine serves as an internal standard in gas chromatography, particularly for high-resolution mass spectrometry. It aids in the accurate determination of taste and odour-causing compounds when using adsorbents like Ambersorb 572.
Analytical Chemistry Reagent
This compound is valuable in analytical laboratories for methods requiring precise quantification of volatile organic compounds. Its use ensures reliable data in studies related to flavour profiles and sensory analysis.
Chemical Synthesis
As a heterocyclic building block, 2-Ethyl-3-methoxypyrazine is employed in organic synthesis. Its pyrazine structure makes it a useful precursor for the development of more complex molecules.
| Molecular weight | 138.17 |
|---|---|
| Empirical formula | C7H10N2O |
| Assay | 99% |
| Boiling point | 90 °C/40 mmHg(lit.) |
| Density | 1.049 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.502(lit.) |
| Application | 2-Ethyl-3-methoxypyrazine has been employed as internal standard for determination of taste and odour causing compounds using the granular adsorbent, Ambersorb 572, by gas chromatography-high resolution mass spectrometry1. |


Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 69 °C / 156.2 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Ethyl-3-methoxypyrazine used for?
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2-Ethyl-3-methoxypyrazine is primarily used as an internal standard in gas chromatography for the determination of taste and odour-causing compounds. It is also employed in chemical synthesis as a heterocyclic building block.
What are the CAS number and formula for 2-Ethyl-3-methoxypyrazine?
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The CAS number for 2-Ethyl-3-methoxypyrazine is 25680-58-4, and its molecular formula is C7H10N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Ethyl-3-methoxypyrazine with a minimum assay of 99%. TSS does not represent this product as USP, BP, or EP grade.
How should 2-Ethyl-3-methoxypyrazine be handled safely?
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Handle 2-Ethyl-3-methoxypyrazine with appropriate personal protective equipment, including eyeshields, faceshields, and gloves. Ensure adequate ventilation and use a suitable respirator. It is harmful if swallowed, causes skin irritation, serious eye damage, and may cause respiratory irritation.
Is 2-Ethyl-3-methoxypyrazine available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Ethyl-3-methoxypyrazine, adhering to all necessary export regulations.
How can I request a quote or sample?
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To request a quote or sample of 2-Ethyl-3-methoxypyrazine, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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