2-Ethoxyphenylboronic acid
2-Ethoxyphenylboronic acid (CAS: 213211-69-9, Formula: C2H5OC6H4B(OH)2, MW: 165.98) is an organoboron compound utilised as a versatile building block in organic synthesis. It serves as a key reactant in various cross-coupling reactions, particularly Suzuki-Miyaura coupling, facilitating the formation of complex organic molecules. This compound is instrumental in the synthesis of heterocyclic compounds and substituted aromatic systems, finding applications in pharmaceutical research and materials science.
- IUPAC
- 2-(Ethoxy)benzeneboronic acid
Suzuki-Miyaura Cross-Coupling
This compound is a valuable reagent in Suzuki-Miyaura cross-coupling reactions. It is employed in the synthesis of pyridines and pyrimidines, and in reactions involving bromo-N-methylpyrrole, leading to the formation of complex biaryl structures.
Synthesis of Diarylbenzophenones
2-Ethoxyphenylboronic acid participates in the synthesis of diarylbenzophenones. These compounds are of interest in materials science and as potential intermediates in pharmaceutical synthesis.
Ipso-Amidation Reactions
The boronic acid is a reactant in ipso-amidation reactions with nitriles. This process offers a route to specific nitrogen-containing organic molecules.
C-H Arylation
It is involved in oxidative coupling reactions via C-H arylation, a method for directly forming carbon-carbon bonds by functionalising unactivated C-H bonds.
| Molecular weight | 165.98 |
|---|---|
| Linear formula | C2H5OC6H4B(OH)2 |
| Application | Reactant involved in Suzuki-Miyaura cross-coupling reactions for synthesis of pyridines and pyrimidines1, reactions of bromo-N-methylpyrrole2, or synthesis of diarylbenzophenones3Reactant involved in:• Ipso-amidation with nitriles4• Studies of the effect of biaryl phosphine ligand structure on C-N and C-C bond formation5• Oxidative coupling via C-H arylation6 |
| Melting point | 97-102 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Ethoxyphenylboronic acid used for?
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2-Ethoxyphenylboronic acid is used as a reactant in Suzuki-Miyaura cross-coupling reactions for the synthesis of pyridines, pyrimidines, and diarylbenzophenones. It is also involved in ipso-amidation with nitriles and oxidative coupling via C-H arylation.
What is the CAS number and chemical formula for 2-Ethoxyphenylboronic acid?
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The CAS number is 213211-69-9, and the chemical formula is C2H5OC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Ethoxyphenylboronic acid typically as a research or technical grade chemical. We do not represent this product as USP, BP, or EP grade. Please refer to the product specifications for detailed purity information.
What are the safety and handling precautions for 2-Ethoxyphenylboronic acid?
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Handle 2-Ethoxyphenylboronic acid with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please consult the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures.
Is 2-Ethoxyphenylboronic acid a controlled substance?
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The provided data does not indicate that 2-Ethoxyphenylboronic acid is a controlled substance.
How is 2-Ethoxyphenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant national and international regulations to ensure safe and secure delivery worldwide.
How can I request a quote or sample of 2-Ethoxyphenylboronic acid?
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To request a quote or sample of 2-Ethoxyphenylboronic acid, please contact our sales team via the website or by phone, providing the product name and CAS number.
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