2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride (CAS: 127337-60-4) is a fluorinated pyridine derivative. This compound, with a molecular weight of 276.08 g/mol and empirical formula C9H9ClF3NO · HCl, serves as a valuable building block in organic synthesis. Its structure, featuring a chloromethyl group and a trifluoroethoxy substituent on the pyridine ring, makes it suitable for constructing more complex molecules in research and development settings, particularly within the pharmaceutical and agrochemical industries.
- Synonyms
- 127337-60-4C9H9ClF3NO · HCl

Organic Synthesis Intermediate
This compound is a versatile intermediate used in the synthesis of diverse organic molecules. The reactive chloromethyl group allows for facile nucleophilic substitution reactions, enabling the introduction of various functional groups.
Pharmaceutical Research
As a halogenated heterocyclic building block, it finds application in medicinal chemistry for the development of novel drug candidates. Its pyridine core and fluorine substituents can impart desirable pharmacokinetic properties.
Agrochemical Development
The unique structural features make it a useful precursor for designing new agrochemicals, potentially contributing to the development of pesticides or herbicides with enhanced efficacy and selectivity.
| Molecular weight | 276.08 |
|---|---|
| Empirical formula | C9H9ClF3NO · HCl |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 208-214 °C |


Hazard statements
- H317May cause an allergic skin reaction
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 41-43 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride used for?
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This compound is primarily used as a building block in organic synthesis, particularly in pharmaceutical and agrochemical research and development for creating more complex molecules.
What are the CAS number and formula for this product?
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The CAS number is 127337-60-4, and the empirical formula is C9H9ClF3NO · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. This product is intended for research and chemical synthesis use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should this chemical be handled safely?
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This compound is classified as Danger, causing serious eye damage and potential skin sensitisation (H318, H317). Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and a dust mask (type N95 US). Ensure adequate ventilation and avoid contact with skin and eyes. Store at 2-8°C.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions, a specialist global supplier and exporter, ensures appropriate packaging and compliance with international shipping regulations for chemicals. For specific details on packing and export, please contact our sales team.
How can I request a sample or a quote?
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To request a sample or obtain a quotation, please contact our dedicated sales department through the contact information provided on our website.
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