2-Chloroethyl methyl ether
2-Chloroethyl methyl ether (CAS 627-42-9), with the linear formula ClCH2CH2OCH3 and a molecular weight of 94.54 g/mol, is an organic compound primarily used as a building block in chemical synthesis. This ether is a valuable intermediate for creating more complex molecules, particularly in the development of pharmaceutical agents and advanced organic materials. Its reliable performance in synthetic routes makes it a key component for researchers and industrial chemists.
- IUPAC
- 2-Methoxyethyl chloride

Organic Synthesis Intermediate
2-Chloroethyl methyl ether serves as a versatile reagent in organic chemistry. It is employed to introduce the 2-methoxyethyl group into various molecular structures, facilitating the synthesis of diverse organic compounds.
Pharmaceutical Research
This compound has been utilised in the synthesis of heterocyclic compounds with potential biological activity. For instance, it has been used in the preparation of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives.
Fine Chemical Production
As an organic building block, 2-Chloroethyl methyl ether is integral to the manufacturing processes of specialised fine chemicals, contributing to the supply chain for various industrial applications.
| Molecular weight | 94.54 |
|---|---|
| Linear formula | ClCH2CH2OCH3 |
| Assay | ≥97.5% (GC) |
| Boiling point | 89-90 °C(lit.) |
| Density | 1.035 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.408(lit.)n20/D 1.408 |
| Application | 2-Chloroethyl methyl ether (2-Methoxyethyl chloride) was used in the synthesis of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives1. |


Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 10 °C / 50 °F |
| Transport (UN / ADR) | UN 3271 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-20/21/22 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloroethyl methyl ether primarily used for?
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2-Chloroethyl methyl ether is primarily used as a building block and intermediate in organic synthesis, including the development of pharmaceutical agents and fine chemicals.
What is the CAS number and chemical formula for 2-Chloroethyl methyl ether?
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The CAS number for 2-Chloroethyl methyl ether is 627-42-9, and its linear formula is ClCH2CH2OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloroethyl methyl ether with a purity of ≥97.5% (GC). We do not represent this product as USP, BP, or EP grade.
How should 2-Chloroethyl methyl ether be handled safely?
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2-Chloroethyl methyl ether is a flammable liquid and harmful if swallowed, inhaled, or in contact with skin. Handling requires appropriate personal protective equipment, including safety goggles, gloves, and respiratory protection, in a well-ventilated area. Always refer to the Safety Data Sheet (SDS) for comprehensive safety guidelines.
How is 2-Chloroethyl methyl ether packed and shipped?
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2-Chloroethyl methyl ether is shipped as UN 3271, Hazard Class 3, Packing Group II, indicating it is a flammable liquid and requires specialised packaging and transportation procedures.
How can I request a quote or sample for 2-Chloroethyl methyl ether?
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To request a quote or sample for 2-Chloroethyl methyl ether, please contact our sales department via the website or directly by phone, providing your specific requirements.
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