2-Chloro-3-hydroxypyridine
2-Chloro-3-hydroxypyridine (CAS: 6636-78-8) is a halogenated heterocyclic compound with the molecular formula C5H4ClNO and a molecular weight of 129.54 g/mol. Supplied by Tech Serve Solutions at 98% purity, this versatile building block is primarily utilised in chemical synthesis. Its structure makes it valuable for constructing more complex molecular architectures, particularly in the development of novel pharmaceutical intermediates and research compounds. It is an important intermediate in organic synthesis.
- IUPAC
- 2-Chloro-3-pyridinol
- Synonyms
- 2-Chloro-3-pyridinol
Synthesis of Selone Derivatives
2-Chloro-3-hydroxypyridine has been employed in the synthesis of 3-hydroxypyridine-2(1H)-selone, a selenium-containing heterocyclic compound.
Preparation of Tricyclic Heterocycles
This compound serves as a precursor in the palladium-mediated synthesis of various benzo[4,5]furopyridine tricyclic systems, including benzo[4,5]furo[2,3-b]pyridine and related isomers.
Organic Synthesis Building Block
As a functionalised pyridine, it is a key intermediate for introducing specific structural motifs in organic chemistry research and development.
| Molecular weight | 129.54 |
|---|---|
| Empirical formula | C5H4ClNO |
| Assay | 98% |
| Application | 2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2(1 H)-selone1. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions2. |
| Melting point | 170-172 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-hydroxypyridine used for?
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2-Chloro-3-hydroxypyridine is used as a building block in chemical synthesis, including the preparation of selone derivatives and the construction of complex tricyclic heterocycles.
What is the CAS number and formula for 2-Chloro-3-hydroxypyridine?
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The CAS number for 2-Chloro-3-hydroxypyridine is 6636-78-8, and its molecular formula is C5H4ClNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-3-hydroxypyridine with an assay of 98%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling precautions for 2-Chloro-3-hydroxypyridine?
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2-Chloro-3-hydroxypyridine is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area and avoid breathing dust.
How is 2-Chloro-3-hydroxypyridine packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packaging details will be provided upon enquiry, adhering to international shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of 2-Chloro-3-hydroxypyridine, please contact our sales team through the website or by phone.
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