2-Bromo-4,6-difluorophenyl isocyanate
2-Bromo-4,6-difluorophenyl isocyanate (CAS 190774-48-2) is a reactive organic compound with the linear formula BrC <sub>6</sub>H <sub>2</sub>(F)<sub>2</sub>NCO and a molecular weight of 234.00 g/mol. Utilised as a building block in chemical synthesis, it features a difluorinated phenyl ring substituted with a bromine atom and an isocyanate functional group. This makes it a valuable intermediate for introducing fluorinated aryl moieties into more complex molecules, particularly in the development of pharmaceuticals and agrochemicals.
- Synonyms
- BrC6H2(F)2NCO
Organic Synthesis Intermediate
This compound serves as a key building block for synthesising complex organic molecules. The isocyanate group readily reacts with nucleophiles, enabling its incorporation into various chemical structures for further derivatisation.
Pharmaceutical Research
Used in the development of novel pharmaceutical agents, the difluorinated phenyl structure can impart desirable properties such as metabolic stability and altered lipophilicity to drug candidates.
Agrochemical Development
This intermediate is valuable in the synthesis of new pesticides and herbicides, where the presence of fluorine atoms can enhance biological activity and efficacy.
Materials Science
Can be employed in the creation of specialised polymers and materials where its unique structural features contribute to specific physical or chemical properties.
| Molecular weight | 234.00 |
|---|---|
| Linear formula | BrC6H2(F)2NCO |
| Assay | 98% |
| Boiling point | 38 °C/0.2 mmHg(lit.) |
| Density | 1.756 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.542(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-4,6-difluorophenyl isocyanate used for?
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2-Bromo-4,6-difluorophenyl isocyanate is primarily used as a building block in organic synthesis, particularly in the research and development of pharmaceuticals, agrochemicals, and specialised materials.
What is the CAS number and formula for this compound?
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The CAS number is 190774-48-2, and the linear formula is BrC <sub>6</sub>H <sub>2</sub>(F)<sub>2</sub>NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with a minimum assay of 98%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling this chemical?
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This compound is classified with GHS07 symbol and a 'Warning' signal word. It poses hazards including (H302, H312, H315, H319, H332, H335), indicating it is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, face shields, and suitable respiratory protection (type ABEK respirator filter), along with protective gloves, must be used. Handle in a well-ventilated area.
Is this product available for export?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 2-Bromo-4,6-difluorophenyl isocyanate.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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