2-Aminopyridine-5-boronic acid pinacol ester
2-Aminopyridine-5-boronic acid pinacol ester (CAS: 827614-64-2, C11H17BN2O2) is a valuable organometallic reagent. With a molecular weight of 220.08 g/mol, it serves as a key building block in organic synthesis. Its primary application involves its use as a substrate in microwave-assisted, four-component coupling reactions for the synthesis of amino-substituted imidazopyridines, making it an important intermediate for pharmaceutical research and development.
- IUPAC
- (2-Aminopyridin-5-yl)boronic acid pinacol ester,2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine,5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine,6-Aminopyridine-3-boronic acid pinacol ester
- Synonyms
- (2-Aminopyridin-5-yl)boronic acid pinacol ester2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine6-Aminopyridine-3-boronic acid pinacol ester
Synthesis of Imidazopyridines
This compound acts as a crucial substrate in microwave-assisted, four-component coupling reactions. This process efficiently yields amino-substituted imidazopyridines, which are important heterocyclic scaffolds in medicinal chemistry.
Organic Synthesis Intermediate
As a boronate ester derivative of 2-aminopyridine, it is widely employed in Suzuki-Miyaura cross-coupling reactions. It facilitates the introduction of the 2-aminopyridin-5-yl moiety into complex molecular structures.
Medicinal Chemistry Research
Its utility in constructing complex nitrogen-containing heterocycles makes it a sought-after reagent for drug discovery programs targeting various therapeutic areas.
| Molecular weight | 220.08 |
|---|---|
| Empirical formula | C11H17BN2O2 |
| Assay | 97% |
| Application | Substrate used in a microwave-assisted, four-component coupling process leading to amino substituted imidazopyridines.1 |
| Melting point | 131-135 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Aminopyridine-5-boronic acid pinacol ester used for?
+
It is primarily used as a substrate in microwave-assisted, four-component coupling reactions to synthesise amino-substituted imidazopyridines, and generally as an intermediate in organic synthesis and medicinal chemistry research.
What is the CAS number and chemical formula?
+
The CAS number is 827614-64-2 and the chemical formula is C11H17BN2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this product with a minimum purity of 97%. This product is supplied for research and development purposes. TSS does not represent it as USP, BP, EP or other pharmacopoeia grades.
How should 2-Aminopyridine-5-boronic acid pinacol ester be handled?
+
This compound is a Warning substance with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn. Ensure adequate ventilation.
Is this chemical a scheduled or controlled substance?
+
The provided data does not indicate that this substance is a scheduled or controlled substance.
How is this chemical shipped and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. All products are packed and shipped according to international regulations for hazardous materials.
How can I request a quote or sample?
+
To request a quote or sample, please contact the Tech Serve Solutions sales team through the website or by direct inquiry, providing the product name and CAS number.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis