2-Aminoethyl diphenylborinate
2-Aminoethyl diphenylborinate (CAS: 524-95-8) is an organoborane compound with the linear formula (C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>BOCH<sub>2</sub>CH<sub>2</sub>NH<sub>2</sub> and a molecular weight of 225.09 g/mol. This chemical serves as a valuable reactant in synthetic chemistry, notably in the preparation of apoptotic inducers. It functions as an activator for the Orai3 protein and acts as an inhibitor of Ca<sup>2+</sup> influx through TRPC2 channels in specific neuronal models.
- IUPAC
- 2-Aminoethoxydiphenyl borate,2-APB,2-Aminoethyl diphenyl borate,Diphenylboric acid 2-aminoethyl ester,Diphenylborinic acid,NSC 17107
- Synonyms
- 2-Aminoethoxydiphenyl borate2-APB2-Aminoethyl diphenyl borateDiphenylboric acid 2-aminoethyl esterDiphenylborinic acid, 2-aminoethyl esterNSC 17107
Preparation of Apoptotic Inducers
2-Aminoethyl diphenylborinate acts as a key reactant in the synthesis of compounds designed to induce apoptosis. This application is crucial in research exploring cell death pathways and potential therapeutic strategies.
Orai3 Protein Activation
This borinate derivative is recognized for its role as an activator of the Orai3 protein, a component of calcium release-activated calcium channels. Its activation can modulate cellular calcium signaling.
TRPC2 Channel Inhibition
In specific experimental models, 2-Aminoethyl diphenylborinate has demonstrated the ability to inhibit calcium ion (Ca<sup>2+</sup>) influx through transient receptor potential 2 (TRPC2) channels in rat dorsal root ganglion neurons.
SOCE Inhibition
As a membrane-permeable inhibitor of store-operated calcium entry (SOCE), this compound is useful for studying calcium dynamics and the role of SOCE in various cellular processes.
| Molecular weight | 225.09 |
|---|---|
| Linear formula | (C6H5)2BOCH2CH2NH2 |
| Storage temperature | −20°C |
| Application | Reactant for:• Preparation of apoptotic inducers1• Activator of the Orai3 (ORAI calcium release-activated calcium modulator 3) protein2• Inhibits Ca2+ influx through transient receptor potential 2 channels in rat dorsal root ganglion neurons3• Membrane-permeable SOCE (store operated calcuym entry) inhibitor4 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Aminoethyl diphenylborinate used for?
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2-Aminoethyl diphenylborinate is used as a reactant in the preparation of apoptotic inducers, as an activator of the Orai3 protein, and to inhibit Ca<sup>2+</sup> influx through transient receptor potential 2 channels and store-operated calcium entry (SOCE).
What is the CAS number and formula for 2-Aminoethyl diphenylborinate?
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The CAS number for 2-Aminoethyl diphenylborinate is 524-95-8, and its linear formula is (C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>BOCH<sub>2</sub>CH<sub>2</sub>NH<sub>2</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Aminoethyl diphenylborinate as a research-grade chemical. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Aminoethyl diphenylborinate be handled?
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Handle 2-Aminoethyl diphenylborinate with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at -20°C. The compound is classified under WGK Germany 3.
How is 2-Aminoethyl diphenylborinate packed, shipped, and exported?
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2-Aminoethyl diphenylborinate is carefully packed according to international shipping regulations to ensure safe transit. Tech Serve Solutions has extensive experience exporting fine chemicals globally.
How can I request a sample or quote for 2-Aminoethyl diphenylborinate?
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To request a sample or a quotation for 2-Aminoethyl diphenylborinate, please contact our sales team through the website or by direct inquiry.
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