(2-Aminobenzyl)triphenylphosphonium bromide
(2-Aminobenzyl)triphenylphosphonium bromide (CAS: 78133-84-3), with the molecular formula H2NC6H4CH2P(C6H5)3Br and a molecular weight of 448.33, is a phosphonium salt used as a reagent in organic synthesis. It is particularly valuable for intramolecular Wittig reactions and the preparation of complex heterocyclic compounds, including substituted indoles and pyrrolocarbazoles. This compound serves as a key building block in the development of novel chemical entities.
Intramolecular Wittig Reactions
(2-Aminobenzyl)triphenylphosphonium bromide is a key reactant in intramolecular Wittig reactions, enabling the cyclisation and formation of complex ring systems. Its structure facilitates the preparation of various heterocyclic compounds.
Preparation of Substituted Indoles
This phosphonium salt is employed in the synthesis of 2,3-disubstituted indoles. These indole derivatives are important structural motifs found in many biologically active molecules.
Synthesis of Pyrrolocarbazoles
It serves as a precursor for the preparation of pyrrolocarbazoles, a class of compounds investigated for their potential as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. This highlights its utility in medicinal chemistry research.
| Molecular weight | 448.33 |
|---|---|
| Linear formula | H2NC6H4CH2P(C6H5)3Br |
| Assay | 97% |
| Application | Reactant for:• Intramolecular Wittig reaction1• Preparation of 2,3-disubstituted indoles2• Preparation of pyrrolocarbazoles as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors3 |
| Melting point | 245 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2-Aminobenzyl)triphenylphosphonium bromide primarily used for?
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(2-Aminobenzyl)triphenylphosphonium bromide is primarily used as a reagent in organic synthesis, specifically for intramolecular Wittig reactions and the preparation of 2,3-disubstituted indoles and pyrrolocarbazoles.
What is the CAS number and chemical formula for (2-Aminobenzyl)triphenylphosphonium bromide?
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The CAS number is 78133-84-3, and the chemical formula is H2NC6H4CH2P(C6H5)3Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (2-Aminobenzyl)triphenylphosphonium bromide with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should (2-Aminobenzyl)triphenylphosphonium bromide be handled?
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Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the safety data sheet for comprehensive handling instructions.
Is (2-Aminobenzyl)triphenylphosphonium bromide a controlled substance?
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Based on the provided data, there is no indication that (2-Aminobenzyl)triphenylphosphonium bromide is a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions expertly packs and exports fine chemicals globally, adhering to stringent international shipping regulations to ensure safe and compliant delivery.
How can I request a sample or quote for (2-Aminobenzyl)triphenylphosphonium bromide?
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To request a sample or a quotation, please contact our sales team through the website or by direct inquiry. We are happy to assist with your specific requirements.
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