2-Amino-6-fluorobenzonitrile
2-Amino-6-fluorobenzonitrile (CAS 77326-36-4, C7H5FN2) is a key organic building block featuring both an amino group and a nitrile group, along with a strategically placed fluorine atom on the benzene ring. Its molecular weight is 136.13 g/mol. This compound serves as an important intermediate in medicinal chemistry, particularly for the synthesis of novel pharmaceutical agents and complex organic molecules. It is primarily utilised in research and development settings for creating drug candidates.
- IUPAC
- 6-Fluoroanthranilonitrile
- Synonyms
- 6-Fluoroanthranilonitrile
Medicinal Chemistry Intermediate
Used in the synthesis of tacrine-related compounds, offering a fluorinated scaffold for drug discovery. Its structure facilitates the development of novel therapeutic agents.
Antifolate and Antibacterial Agents
Incorporated into the design and synthesis of quinazoline derivatives with potential antifolate and antibacterial activities. This application highlights its utility in developing new antimicrobial and antineoplastic drugs.
Organic Synthesis
Serves as a versatile building block in organic synthesis, enabling the introduction of fluorinated aromatic moieties into complex molecular architectures. Useful for creating fine chemicals and advanced intermediates.
| Molecular weight | 136.13 |
|---|---|
| Linear formula | H2NC6H3(F)CN |
| Assay | 99% |
| Storage temperature | 2-8°C |
| Application | A medicinal chemistry intermediate used for the preparation of tacrine-related compounds1 and antifolate and antibacterial quinazoline derivatives.2 |
| Melting point | 125-128 °C(lit.) |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-6-fluorobenzonitrile used for?
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2-Amino-6-fluorobenzonitrile is primarily used as a medicinal chemistry intermediate for preparing tacrine-related compounds and antifolate and antibacterial quinazoline derivatives. It is also a useful building block in general organic synthesis.
What is the CAS number and formula for 2-Amino-6-fluorobenzonitrile?
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The CAS number is 77326-36-4, and the molecular formula is C7H5FN2 (or H2NC6H3(F)CN).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-6-fluorobenzonitrile with an assay of 99%. This product is intended for research and technical use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Amino-6-fluorobenzonitrile be handled safely?
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2-Amino-6-fluorobenzonitrile is classified as a Warning substance with hazard statement H319, indicating it causes serious eye irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 US), should be used. Ensure good ventilation and follow safety precautions, particularly P305 + P351 + P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing).
How is 2-Amino-6-fluorobenzonitrile shipped and exported?
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2-Amino-6-fluorobenzonitrile is stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring compliant and secure packaging for international shipment.
How can I request a sample or quote for 2-Amino-6-fluorobenzonitrile?
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To request a sample or a quotation for 2-Amino-6-fluorobenzonitrile, please contact the Tech Serve Solutions sales team through our website or by phone. We will respond promptly with detailed information and pricing.
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