2-Acetamido-4-methyl-5-thiazolesulfonyl chloride

CAS 69812-29-9C6H7ClN2O3S2Chemical Synthesis

2-Acetamido-4-methyl-5-thiazolesulfonyl chloride (CAS: 69812-29-9) is a heterocyclic organic compound with the molecular formula C6H7ClN2O3S2 and a molecular weight of 254.71 g/mol. This compound serves as a valuable building block in chemical synthesis, particularly for researchers working with thiazole derivatives. Its primary documented application involves its use in the high-performance liquid chromatographic (HPLC) assay of acetazolamide. TSS supplies this chemical for laboratory and research purposes.

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2-Acetamido-4-methyl-5-thiazolesulfonyl chloride (C6H7ClN2O3S2) — chemical structure, CAS 69812-29-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC3 to C7Chemical SynthesisHeterocyclic Building BlocksThiazoles

01 /Applications

HPLC Assay of Acetazolamide

2-Acetamido-4-methyl-5-thiazolesulfonyl chloride is employed as a reagent in high-performance liquid chromatographic (HPLC) assays. It plays a role in the analytical determination of acetazolamide, a well-known diuretic and glaucoma medication.

Heterocyclic Building Block

This compound functions as a versatile building block for the synthesis of novel heterocyclic compounds. Its thiazole core and reactive sulfonyl chloride group make it suitable for constructing more complex molecular architectures.

Chemical Synthesis Intermediate

As an intermediate in chemical synthesis, 2-Acetamido-4-methyl-5-thiazolesulfonyl chloride is utilised in multi-step organic reactions. It is particularly relevant for researchers exploring C3 to C7 organic molecules and sulphur-containing heterocycles.

02 /Properties

Molecular weight	254.71
Empirical formula	C6H7ClN2O3S2
Assay	97%
Application	2-Acetamido-4-methyl-5-thiazolesulfonyl chloride was used in high-performance liquid chromatographic (HPLC) assay for acetazolamide1.
Melting point	161-164 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3261 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-27-28-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

69812-29-9

MDL number

MFCD00005320

PubChem substance

24846785

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-Acetamido-4-methyl-5-thiazolesulfonyl chloride primarily used for?

Its primary documented use is in the high-performance liquid chromatographic (HPLC) assay of acetazolamide. It also serves as a building block in chemical synthesis for creating complex heterocyclic compounds.

What are the CAS number and molecular formula for this compound?

The CAS number is 69812-29-9, and the molecular formula is C6H7ClN2O3S2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2-Acetamido-4-methyl-5-thiazolesulfonyl chloride with an assay of 97%. This product is typically considered technical or research grade, and TSS does not represent it as USP, BP, or EP grade.

What are the main safety hazards associated with this chemical?

This compound is classified as Danger, indicated by the GHS05 symbol. It causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, and resistant gloves, is essential. Handle with extreme caution in a well-ventilated area.

How is this chemical shipped and exported?

As per UN 3261, 8/PGII classification, this corrosive solid is packaged and shipped according to international regulations for hazardous materials, ensuring safe export worldwide.

How can I request a sample or quote for 2-Acetamido-4-methyl-5-thiazolesulfonyl chloride?

To request a sample or obtain a quote, please contact our sales team via the website or direct email, providing your requirements and delivery details.