2,6-Dimethylphenylmagnesium bromide solution
2,6-Dimethylphenylmagnesium bromide solution (CAS: 21450-64-6) is an organometallic compound with the linear formula (CH3)2C6H3MgBr and a molecular weight of 209.37 g/mol. Supplied as a 1.0 M solution in Tetrahydrofuran (THF), this Grignard reagent is a reactive species employed in organic synthesis for carbon-carbon bond formation. Its utility lies in its ability to introduce the 2,6-dimethylphenyl group into various organic molecules, facilitating the construction of complex chemical structures.
- Synonyms
- (CH3)2C6H3MgBr
Organic Synthesis Reagent
2,6-Dimethylphenylmagnesium bromide is a Grignard reagent used in nucleophilic addition reactions. It facilitates the formation of new carbon-carbon bonds by reacting with electrophiles such as aldehydes, ketones, esters, and epoxides.
Arylation Reactions
This compound serves as an effective source for introducing the sterically hindered 2,6-dimethylphenyl moiety into organic frameworks. This is particularly useful in the synthesis of complex molecules where specific aryl substitution patterns are required.
Pharmaceutical Intermediate Synthesis
The 2,6-dimethylphenyl group can be a structural feature in certain pharmaceutical compounds. This Grignard reagent provides a synthetic route for incorporating this group during the development of drug candidates or their intermediates.
Material Science Applications
Organometallic reagents like 2,6-dimethylphenylmagnesium bromide can find use in the synthesis of novel materials, including polymers or ligands for catalysis, where precise structural control is needed.
| Molecular weight | 209.37 |
|---|---|
| Linear formula | (CH3)2C6H3MgBr |
| Boiling point | 65-67 °C |
| Density | 0.998 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -19 °C / -2.2 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-20/21/22-34-37 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Dimethylphenylmagnesium bromide solution used for?
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2,6-Dimethylphenylmagnesium bromide solution is primarily used as a Grignard reagent in organic synthesis for the formation of carbon-carbon bonds and the introduction of the 2,6-dimethylphenyl group into various organic molecules.
What is the CAS number and formula for 2,6-Dimethylphenylmagnesium bromide solution?
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The CAS number for 2,6-Dimethylphenylmagnesium bromide solution is 21450-64-6. Its linear formula is (CH3)2C6H3MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Dimethylphenylmagnesium bromide solution at a concentration of 1.0 M in THF. We do not represent this product as meeting any specific pharmacopoeia standards (USP, EP, BP) unless explicitly stated on the product documentation.
How should 2,6-Dimethylphenylmagnesium bromide solution be handled?
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This is a highly reactive and flammable substance that reacts violently with water and may form explosive peroxides. It is corrosive and toxic by inhalation, ingestion, and skin contact. Handling requires stringent safety precautions, including the use of appropriate personal protective equipment such as gloves, goggles, face shields, and respirators, in a well-ventilated area or fume hood. Refer to the Safety Data Sheet (SDS) for comprehensive handling instructions.
Is 2,6-Dimethylphenylmagnesium bromide solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,6-Dimethylphenylmagnesium bromide solution. We handle all export documentation and logistics.
How can I request a sample or quote for 2,6-Dimethylphenylmagnesium bromide solution?
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To request a sample or obtain a quote for 2,6-Dimethylphenylmagnesium bromide solution, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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