2,4,6-Trichlorobenzoic acid
2,4,6-Trichlorobenzoic acid (CAS: 50-43-1, Cl3C6H2CO2H) is a halogenated aromatic carboxylic acid with a molecular weight of 225.46 g/mol. This compound serves as a key reactant and intermediate in various organic syntheses. Its applications range from reductive cleavage reactions and the synthesis of complex heterocyclic compounds like pyrazole benzamides and coumarins, to its use in flame retardant monomer production and as a cocatalyst in alkene functionalisation.
- Synonyms
- 50-43-1Cl3C6H2CO2H
Organic Synthesis Intermediate
2,4,6-Trichlorobenzoic acid is employed as a reactant in the synthesis of diverse organic molecules. It is notably involved in the preparation of aryl aminopyrazole benzamides and saphenamycin analogues with antimicrobial properties.
Flame Retardant Monomer Synthesis
This compound is utilised in the chemical manufacturing sector for the synthesis of monomers intended for flame-retardant applications, contributing to material safety.
Cocatalyst in Alkene Reactions
It functions as a cocatalyst in significant organic transformations such as the cis-dihydroxylation and epoxidation of alkenes, facilitating these reactions under specific conditions.
Synthesis of Antifungals
The acid is a precursor in the synthesis of 3,4,7-trisubstituted coumarins, which are investigated for their potential antifungal activities.
| Molecular weight | 225.46 |
|---|---|
| Linear formula | Cl3C6H2CO2H |
| Application | Reactant involved in:• Active-sodium-promoted reductive cleavage of halogenated benzoic acids1• Synthesis of aryl aminopyrazole benzamides for use as non-steroidal selective glucocorticoid receptor agonists2• Flame retardant monomer synthesis3• Synthesis of 3,4,7-trisubstituted coumarins for use as antifungals4• Solid-phase synthesis of saphenamycin analogs with antimicrobial activity5Cocatalyst for cis-dihydroxylation and epoxidation of alkenes6 |
| Melting point | 160-164 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Trichlorobenzoic acid used for?
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2,4,6-Trichlorobenzoic acid is used as a reactant in organic synthesis, including the preparation of aryl aminopyrazole benzamides, saphenamycin analogs, flame retardant monomers, and coumarins with antifungal activity. It also serves as a cocatalyst in alkene dihydroxylation and epoxidation.
What is the CAS number and formula for 2,4,6-Trichlorobenzoic acid?
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The CAS number is 50-43-1 and the linear formula is Cl3C6H2CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,6-Trichlorobenzoic acid as a technical or research-grade chemical. We do not represent it as meeting USP, BP, or EP pharmacopoeia standards unless explicitly stated in the product specifications.
How should 2,4,6-Trichlorobenzoic acid be handled?
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2,4,6-Trichlorobenzoic acid is a warning substance that causes skin irritation, serious eye irritation, and respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust.
Is 2,4,6-Trichlorobenzoic acid exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,4,6-Trichlorobenzoic acid.
How can I request a sample or quote for 2,4,6-Trichlorobenzoic acid?
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To request a sample or a quote for 2,4,6-Trichlorobenzoic acid, please contact our sales department through the website or by phone.
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